| PAIN | "Bread," to a Parisian |
| PAIN | "I feel your ___" (compassionate words) |
| PAIN | "King of ___" (1983 hit song for the Police) |
| PAIN | "King of ___" (hit song by The Police) |
| PAIN | "No __, no gain" |
| PAIN | "No ___, No Gain" |
| PAIN | "No ___, no gain!" (words outside a gym, maybe) |
| PAIN | "No ___, no gain" |
| PAIN | "No ___, no gain" (exercise motto) |
| PAIN | "No ___, no gain" (hurt) |
| PAIN | "No ___, no gain" (words on a motivational poster, maybe) |
| PAIN | "One good thing about music, when it hits you, you feel no ___," quote from the song "Trenchtown Rock" by Bob Marley and the Wailers |
| PAIN | "Regarding the ___ of Others" (Susan Sontag book on photography) |
| PAIN | "Something for the ___," 1995 song by Bon Jovi from their sixth studio album |
| PAIN | "Sweet is pleasure after ___": Dryden |
| PAIN | "What a ___ in the neck!" |
| PAIN | "___ in the neck" (hassle) |
| PAIN | Ache |
| PAIN | Ache that can be "shooting" |
| PAIN | Ache, hurt |
| PAIN | Advil target |
| PAIN | Aggrieve |
| PAIN | Agony |
| PAIN | Aleve may relieve it |
| PAIN | An unpleasant feeling, something you would take a ___killer for |
| PAIN | Analgesic target |
| PAIN | Analgesic's target |
| PAIN | Anguish |
| PAIN | Annoyance |
| PAIN | Annoying person |
| PAIN | Annoying sort |
| PAIN | Anodyne target |
| PAIN | Appendicitis symptom |
| PAIN | Apt rhyme for "sprain" |
| PAIN | Aptly named advocacy org. founded by Nan Goldin in response to the opioid crisis |
| PAIN | Arduous chore |
| PAIN | Arthritis symptom |
| PAIN | Aspirin target |
| PAIN | Aspirin target? |
| PAIN | Aspirin's target |
| PAIN | Aspirin’s target |
| PAIN | Baby brother, often |
| PAIN | Big hassle |
| PAIN | Big inconvenience |
| PAIN | Big nuisance |
| PAIN | Body distress |
| PAIN | Bother |
| PAIN | Bothersome person |
| PAIN | Bothersome task |
| PAIN | Cause for an analgesic |
| PAIN | Cause for an examination |
| PAIN | Cause of a grimace |
| PAIN | Cause of a wince |
| PAIN | Cause of grimacing |
| PAIN | Cause of some grimacing |
| PAIN | Cause to grimace |
| PAIN | Charley horse consequence |
| PAIN | Considerable inconvenience |
| PAIN | Counterpart of pleasure |
| PAIN | Discomfit |
| PAIN | Discomfort |
| PAIN | Discomfort cause |
| PAIN | Distress |
| PAIN | Distress, anguish |
| PAIN | Doctors measure it from 0 to 10 |
| PAIN | Effect of an injury |
| PAIN | Excedrin target |
| PAIN | Extreme physical discomfort |
| PAIN | Father at home is a nuisance |
| PAIN | Father, at home, is a nuisance |
| PAIN | Father, at home, is irksome |
| PAIN | Feeling no ___ (intoxicated) |
| PAIN | Feeling that makes you say "Ow!" |
| PAIN | French bread |
| PAIN | Frustrating thing |
| PAIN | Great discomfort |
| PAIN | Grimace cause |
| PAIN | Grimace inducer |
| PAIN | Hassle |
| PAIN | Headache symptom |
| PAIN | Hurt |
| PAIN | Hurt feelings? |
| PAIN | Hurting feeling |
| PAIN | Ibuprofen target |
| PAIN | Icy Hot target |
| PAIN | Irksome sort |
| PAIN | It can follow a fall |
| PAIN | It may be unbearable |
| PAIN | It might make you smart |
| PAIN | It's in the neck, at times |
| PAIN | It's weakness leaving the body, in a motivational platitude |
| PAIN | Item crammed into a kitchen cabinet |
| PAIN | Kidney stone symptom |
| PAIN | Liniment target |
| PAIN | Major annoyance |
| PAIN | Major hassle |
| PAIN | Major inconvenience |
| PAIN | Major nuisance |
| PAIN | Masochist's pleasure |
| PAIN | Neuralgia |
| PAIN | Nice bread |
| PAIN | No gain without this, they say |
| PAIN | Nociceptor's detection |
| PAIN | Nuisance |
| PAIN | Nuisance, so to speak |
| PAIN | Number's target? |
| PAIN | One who keeps bugging you even after you tell them to get lost |
| PAIN | Pang |
| PAIN | Partner of suffering |
| PAIN | Pest |
| PAIN | Physical discomfort |
| PAIN | Physical suffering |
| PAIN | Pill |
| PAIN | Pill ... or a reason to take a pill |
| PAIN | Pleasure's opposite |
| PAIN | Prefix with "killer" to mean a type of pill |
| PAIN | Proverbial problem for the neck or butt |
| PAIN | Real hassle |
| PAIN | Reason for applying a medicated plaster |
| PAIN | Reason for taking an aspirin |
| PAIN | Reason for using a heating pad |
| PAIN | Reason for using an ice pack |
| PAIN | Reason to take Advil |
| PAIN | Reason to take acetaminophen |
| PAIN | Reason to take butorphanol |
| PAIN | Result of punishment |
| PAIN | Royal ___ |
| PAIN | Royal annoyance? |
| PAIN | Royal problem? |
| PAIN | Salonpas target |
| PAIN | See 4-Across |
| PAIN | Sensation after a wasp sting |
| PAIN | Severe discomfort |
| PAIN | Severe suffering |
| PAIN | Sharp ache |
| PAIN | Sharp sensation |
| PAIN | Sibling, at times? |
| PAIN | Something necessary for gain, they say |
| PAIN | Soreness |
| PAIN | Soreness or achiness |
| PAIN | Suffering |
| PAIN | Symptom of hurt |
| PAIN | There's no gain without it |
| PAIN | Torment |
| PAIN | Total hassle |
| PAIN | Total headache |
| PAIN | Total inconvenience |
| PAIN | Tough person to tolerate |
| PAIN | Tylenol target |
| PAIN | Unpleasant bodily sensation |
| PAIN | Wahlberg's "___ & Gain" |
| PAIN | What a dolorimeter measures |
| PAIN | What a headache causes |
| PAIN | What a sadist enjoys inflicting |
| PAIN | What a vulnerable person might be honest about |
| PAIN | What a werewolf bite would probably inflict |
| PAIN | What acupuncture relieves, for some |
| PAIN | What an analgesic relieves |
| PAIN | What an analgesic stops |
| PAIN | What analgesics relieve |
| PAIN | What aspirin is taken for |
| PAIN | What aspirin reduces |
| PAIN | What aspirin relieves |
| PAIN | What ibuprofen and acetaminophen target |
| PAIN | What lines with stars at the end indicate in comics |
| PAIN | What nociceptors sense |
| PAIN | What you experience when your toe gets stubbed |
| PAIN | Wince cause, maybe |
| PAIN | Wong To Yick target |
| PAIN | Word shouted many times in "Believer" by Imagine Dragons |
| PAIN | __ in the neck (annoyance) |
| PAIN | __ in the neck (pest) |
| PAIN | ___ and suffering (factor in some legal judgments) |
| PAIN | ___ in the neck |
| PAIN | ___ in the neck (annoyance) |
| PAIN | ___ in the neck (annoying person) |
| PAIN | ___ in the neck (hassle) |
| PAIN | ___ in the neck (inconvenience) |
| PAIN | ___ in the neck (nuisance) |
| PAIN | ___ killer |
| PAIN | ___ threshold (level at which someone experiences hurt) |