| SIS | "Don't call me __ cause I'm not your sister" (Megan Thee Stallion lyric) |
| SIS | "Go Off, ___" (podcast) |
| SIS | "Pretty sneaky, ___" (line from a 1980s Connect Four ad) |
| SIS | "Rah, Rah, ___ Boom Bah" |
| SIS | "Rah, rah, ___-boom-bah!" |
| SIS | "Revenge of the ___" ("Star Wars: Jedi Academy" book) |
| SIS | "___ boom bah!" |
| SIS | "___ boom bah!" (cheer) |
| SIS | "___ for Silence" (Sue Grafton book): 2 wds. |
| SIS | "___ for Silence" (Sue Grafton mystery): 2 wds. |
| SIS | "___ for Silence" (Sue Grafton novel): 2 wds. |
| SIS | "___-boom-bah!" |
| SIS | "__-boom-bah!" |
| SIS | ''__ for Silence'' (Grafton novel) |
| SIS | 14-Across to Danielle and Alana |
| SIS | 54-Across' sib |
| SIS | A female sibling, for short |
| SIS | A sib |
| SIS | A tot may have a big one |
| SIS | Actress who organized the Trans March on Broadway in 2021 |
| SIS | Adolescent nickname |
| SIS | Affectionate family name |
| SIS | Alex Dunphy, to Luke, on "Modern Family", for short |
| SIS | Amy, to Meg and Beth in "Little Women," for short |
| SIS | Amy, to Meg or Beth in "Little Women," for short |
| SIS | Ancient capital of the Armenian Kingdom of Cilicia |
| SIS | Ashley, to Mary-Kate |
| SIS | Aunt, to mom, for short |
| SIS | Auntie, to Dad |
| SIS | Auntie, to Mom |
| SIS | Auntie, to dad |
| SIS | Auntie, to mom |
| SIS | Auntie, to one's parent |
| SIS | Bella Hadid, to Gigi Hadid, for short |
| SIS | Bella, to Gigi, for short |
| SIS | Beth, to Jo, for short |
| SIS | Bey, to Solange |
| SIS | Beyonce, to Solange, or vice versa |
| SIS | Beyoncé, to Solange, informally |
| SIS | Beyoncé, to Solange, or vice versa |
| SIS | Black queer term of endearment |
| SIS | Boom preceder |
| SIS | Bro and ___ are siblings |
| SIS | Bro counterpart |
| SIS | Bro hugger, perhaps |
| SIS | Bro kin |
| SIS | Bro sibling |
| SIS | Bro's antonym |
| SIS | Bro's counterpart |
| SIS | Bro's family counterpart |
| SIS | Bro's female counterpart |
| SIS | Bro's female counterpart, for short |
| SIS | Bro's female sibling |
| SIS | Bro's female sibling, for short |
| SIS | Bro's kin |
| SIS | Bro's pal |
| SIS | Bro's palindromic counterpart |
| SIS | Bro's partner |
| SIS | Bro's playmate |
| SIS | Bro's relative |
| SIS | Bro's sib |
| SIS | Bro's sib of the opposite sex |
| SIS | Bro's sibling |
| SIS | Bro's sibling, for short |
| SIS | Bro's sibling, maybe |
| SIS | Bro's twin |
| SIS | Bro's twin, perhaps |
| SIS | Brother's counterpart, for short |
| SIS | Brother's female counterpart, lovingly |
| SIS | Brother's sib |
| SIS | Brother's sibling, for short |
| SIS | Bro’s kin |
| SIS | Bro’s sib |
| SIS | Bro’s sibling |
| SIS | Casual reference to sister |
| SIS | Certain family member, informally |
| SIS | Certain sib |
| SIS | Certain twin |
| SIS | Charlie had two bros and a ___ |
| SIS | Charlotte Bronte, to Emily, for short |
| SIS | Cheer start |
| SIS | Cheer starter |
| SIS | Cheer syllable |
| SIS | Cheerleader's syllable |
| SIS | Chloe, to Halle, for short |
| SIS | Close relative |
| SIS | Close relative, briefly |
| SIS | Close relative, for short |
| SIS | Dad's daughter |
| SIS | Daughter of mom |
| SIS | Dot, to Ditto, in "Hi and Lois" |
| SIS | Elizabeth, to Ashley Olsen, for short |
| SIS | Elle, to Dakota |
| SIS | Elsa, to Anna, for short |
| SIS | Emily Deschanel's relationship to Zooey, for short |
| SIS | Emily, to Charlotte |
| SIS | Eunice, to JFK |
| SIS | Eva, to Zsa Zsa |
| SIS | Fam girl |
| SIS | Fam member |
| SIS | Fam. member |
| SIS | Familial comrade |
| SIS | Familial moniker |
| SIS | Familial nickname |
| SIS | Familial sobriquet |
| SIS | Familial term of address |
| SIS | Familial title |
| SIS | Family address |
| SIS | Family female, for short |
| SIS | Family gal |
| SIS | Family girl |
| SIS | Family girl, briefly |
| SIS | Family girl, for short |
| SIS | Family girl, informally |
| SIS | Family mem. |
| SIS | Family member |
| SIS | Family member, briefly |
| SIS | Family member, familiarly |
| SIS | Family member, for short |
| SIS | Family member, informally |
| SIS | Family moniker |
| SIS | Family name |
| SIS | Family nickname |
| SIS | Family nickname/palindrome |
| SIS | Family palindrome |
| SIS | Family pet name |
| SIS | Fellow sorority member, for short |
| SIS | Female child to another, for short |
| SIS | Female counterpart of "bro" |
| SIS | Female equivalent of "bro" |
| SIS | Female family member (briefly)` |
| SIS | Female in the fam |
| SIS | Female person who has the same parents as another person |
| SIS | Female sib |
| SIS | Female sib. |
| SIS | Female sibling |
| SIS | Female sibling (abbr) |
| SIS | Female sibling's nickname |
| SIS | Female sibling, affectionately |
| SIS | Female sibling, fondly |
| SIS | Female sibling, for short |
| SIS | Female sibling, informally |
| SIS | Female sibling, lovingly |
| SIS | Female sibling: Abbr. |
| SIS | Female version of "bro" |
| SIS | Foreign agreements |
| SIS | Frequent maid of honor, in brief |
| SIS | Girl in the fam |
| SIS | Girl of the fam |
| SIS | Girl of the fam, for short |
| SIS | Girl of the family, for short |
| SIS | Girl sib |
| SIS | Girl sibling |
| SIS | Girl sibling, briefly |
| SIS | Girl sibling, for short |
| SIS | Girl who's a sib |
| SIS | Girl with the same mother, briefly |
| SIS | Girl with the same parents |
| SIS | Girl's nickname |
| SIS | Grafton's "___ for Silence" |
| SIS | Grafton's ''__ for Silence'' |
| SIS | Granny, to a great-aunt |
| SIS | Halle, to Chloe, for short |
| SIS | Household name |
| SIS | Household name? |
| SIS | Household nickname |
| SIS | In-law's wife, possibly |
| SIS | Ivanka Trump, to Eric Trump |
| SIS | Jane Fonda, to Peter, for short |
| SIS | Just one of the fam |
| SIS | Kate Middleton, to Pippa |
| SIS | Kate to Ashley |
| SIS | Kate, to Randall and Kevin on "This Is Us," for short |
| SIS | Kendall, to Kylie, for short |
| SIS | Khloe to Kim, for short |
| SIS | Kid who isn't bro-ey? |
| SIS | Kim Kardashian West, to Kourtney Kardashian |
| SIS | Kim Kardashian to Khloe, for short |
| SIS | Kim to Khloe, for short |
| SIS | Kim, to Khloé Kardashian |
| SIS | Kim, to Khloé Kardashian, for short |
| SIS | Kim, to Kourtney Kardashian |
| SIS | Kim, to Kourtney or Khloé |
| SIS | Kin |
| SIS | Kourtney, to Kim |
| SIS | Kourtney, to Kim and Khloe, briefly |
| SIS | La Toya, to Michael |
| SIS | Latin American agreements |
| SIS | Leia, to Luke, casually |
| SIS | Lil ___ (two-palindrome family member) |
| SIS | Lisa Simpson, to Bart |
| SIS | Lisa, to Bart |
| SIS | Lisa, to Bart Simpson |
| SIS | Little sister? |
| SIS | Madrid replies |
| SIS | Maggie Gyllenhaal, to Jake Gyllenhaal |
| SIS | Maggie, to Bart |
| SIS | Maggie, to Lisa |
| SIS | Malia Obama, to Sasha |
| SIS | Malia, to Sasha |
| SIS | Mama, to auntie |
| SIS | Marcia, to Greg Brady, for short |
| SIS | Marie, to Donny |
| SIS | Mary-Kate to Ashley Olsen, casually |
| SIS | Mary-Kate to Ashley Olsen, fondly |
| SIS | Meg Tilly, to Jennifer |
| SIS | Meg, to Chris and Stewie, on "Family Guy" |
| SIS | Member of the fam |
| SIS | Member of the family, for short |
| SIS | Mom's daughter |
| SIS | Mom's girl |
| SIS | Mom, to Auntie |
| SIS | Mom-to-aunt term |
| SIS | Monica, to Ross, on "Friends" |
| SIS | Nickname for a female sibling |
| SIS | Nickname for a niece's mom, perhaps |
| SIS | Nickname for a sibling, for short |
| SIS | Nickname in the family |
| SIS | Nickname within the family |
| SIS | Niece, to a nephew, for short |
| SIS | Noah, to Miley, fondly |
| SIS | Not a bro (abbr) |
| SIS | Nuclear unit nickname |
| SIS | One at the kids' table, perhaps |
| SIS | One in the fam |
| SIS | One in the family |
| SIS | One in the family, informally |
| SIS | One kind of sibling, for short |
| SIS | One of a pair of fraternal twins, maybe |
| SIS | One of the fam |
| SIS | One of the family |
| SIS | One of the kin |
| SIS | One relatively close either way? |
| SIS | One sharing a bunk bed, maybe |
| SIS | One's sib, maybe |
| SIS | Paige, to Jason, in "FoxTrot" |
| SIS | Palindromic family member |
| SIS | Palindromic family nickname |
| SIS | Palindromic nickname |
| SIS | Palindromic relative |
| SIS | Palindromic sib |
| SIS | Palindromic sibling |
| SIS | Palindromic term of address |
| SIS | Parent sharer |
| SIS | Part of the fam |
| SIS | Person's sister (often used as a form of address) |
| SIS | Pippa, to Kate |
| SIS | Pop sharer |
| SIS | Pop's daughter |
| SIS | Pop’s daughter |
| SIS | Potential aunt, for short |
| SIS | Provider or wearer of some hand-me-downs |
| SIS | Ray Bradbury's "___ for Space" |
| SIS | Relative's nickname |
| SIS | Relative, briefly |
| SIS | Relative, familiarly |
| SIS | Relative, for short |
| SIS | Reunion moniker |
| SIS | Sally, to Charlie Brown |
| SIS | Sasha Obama, to Malia |
| SIS | Sasha, to Malia |
| SIS | Sasha, to Malia, informally |
| SIS | See 1-Across |
| SIS | Serena Williams, to Venus |
| SIS | Serena to Venus, for short |
| SIS | Serena, to Venus |
| SIS | Serena, to Venus, for short |
| SIS | She is your mom's kid |
| SIS | She often wears hand-me-downs |
| SIS | She's a close relative, briefly |
| SIS | Shirley MacLaine, to Warren Beatty |
| SIS | Short form for a female sibling |
| SIS | Short form of sister |
| SIS | Short name for sibling |
| SIS | Short sibling? |
| SIS | Sib's nickname |
| SIS | Sibling |
| SIS | Sibling nickname |
| SIS | Sibling who is not your bro |
| SIS | Sibling's address |
| SIS | Sibling's nickname |
| SIS | Sibling, for short |
| SIS | Sibling, in brief |
| SIS | Skipper, to Barbie |
| SIS | Slangy term of endearment |
| SIS | Sobriquet for a sibling |
| SIS | Softball star Bates |
| SIS | Solange, to Bey |
| SIS | Solange, to Beyonce, informally |
| SIS | Solange, to Beyoncé |
| SIS | Solange, to Beyoncé, for short |
| SIS | Some votes in Venezuela |
| SIS | Sonny's sib |
| SIS | Sonny's sibling |
| SIS | Soror, e.g. |
| SIS | Spanish ayes |
| SIS | Spanish ayes? |
| SIS | Spanish replies |
| SIS | Spanish yeses |
| SIS | Special attention to certain details: empha___ |
| SIS | Start of a cheer |
| SIS | Start of a cry that ends "bah!" |
| SIS | Sue Grafton's "___ for Silence" |
| SIS | Sue Heck to Brick and Axl, on "The Middle" |
| SIS | Tegan, to Sara, for short |
| SIS | Term of address for a drag queen |
| SIS | Term of address that's a palindrome |
| SIS | Tia, to Tamera |
| SIS | Tia, to Tamera, briefly |
| SIS | Tia, to Tamera, for short |
| SIS | Tina Belcher, to Gene, on "Bob's Burgers" |
| SIS | Unlikely nickname on "My Three Sons"? |
| SIS | Venus Williams, to Serena, for short |
| SIS | Venus to Serena, e.g. |
| SIS | Venus, to Serena |
| SIS | Venus, to Serena, casually |
| SIS | Venus, to Serena, for short |
| SIS | What Khloe might call Kim |
| SIS | What Khloé might call Kim |
| SIS | What Kim might call Khloé |
| SIS | What Serena Williams might call Venus Williams |
| SIS | What the Olsen twins might call each other |
| SIS | What your aunt is to your mom, for short |
| SIS | What your aunt might call your mother |
| SIS | What your father might call your aunt |
| SIS | What your mom might call your aunt |
| SIS | What your mother might call your aunt |
| SIS | Willow, to Jaden, for short |
| SIS | Your aunt would be one, but not your bro |
| SIS | Yucatán yeses |
| SIS | __ boom bah |
| SIS | ___ Got Tea (Louisville tea shop) |
| SIS | ___ boom bah |
| SIS | ___ boom bah! |
| SIS | ___-boom-bah |