| SNAKE | "A ___ Falls to Earth" (2022 Newbery Medal nominee by Darcie Little Badger) |
| SNAKE | "The Simpsons" criminal who has a reptilian nickname |
| SNAKE | "___ Eyes: G.I. Joe Origins" (2021 film starring Henry Golding) |
| SNAKE | "___ in the grass," phrase for an unfaithful friend with a hissing reptile in it |
| SNAKE | "reputation" reptile |
| SNAKE | & 20D 1998 thriller starring Nicolas Cage and Gary Sinise |
| SNAKE | 2001's symbol, in the Chinese calendar |
| SNAKE | 52-Down, e.g. |
| SNAKE | A slithering animal |
| SNAKE | Adder or viper, for example |
| SNAKE | Adder, but not a subtracter? |
| SNAKE | Adder, e.g. |
| SNAKE | An anaconda is this kind of animal |
| SNAKE | Anaconda |
| SNAKE | Anaconda or Inland taipan, e.g. |
| SNAKE | Anaconda, e.g. |
| SNAKE | Anaconda, for one |
| SNAKE | Animal heard at the end of 17-Across |
| SNAKE | Animal that smells with its tongue |
| SNAKE | Animal with sea and coral varieties |
| SNAKE | Asp |
| SNAKE | Asp or adder |
| SNAKE | Backstabber |
| SNAKE | Ball python, for example |
| SNAKE | Basilisk, e.g. |
| SNAKE | Black animal in a Blind Lemon Jefferson song |
| SNAKE | Boa |
| SNAKE | Boa constrictor, for one |
| SNAKE | Boa or cobra |
| SNAKE | Boa or python |
| SNAKE | Boa, for one |
| SNAKE | Character played by Kurt Russell in John Carpenter action films Escape from New York and Escape from LA |
| SNAKE | Chinese zodiac animal |
| SNAKE | Chinese zodiac reptile |
| SNAKE | Classic arcade game where you have to avoid colliding with the wall |
| SNAKE | Classic mobile game involving slithering around a playing field |
| SNAKE | Clog buster |
| SNAKE | Clog cleaner |
| SNAKE | Clog clearer |
| SNAKE | Cobra |
| SNAKE | Cobra or boa |
| SNAKE | Cobra or boa, for example |
| SNAKE | Cobra or constrictor |
| SNAKE | Cobra or copperhead |
| SNAKE | Cobra or copperhead, for example |
| SNAKE | Cobra or python |
| SNAKE | Cobra or python, for example |
| SNAKE | Cobra or viper, e.g. |
| SNAKE | Cobra or viper, for example |
| SNAKE | Cobra, e.g. |
| SNAKE | Copperhead or cobra, e.g. |
| SNAKE | Copperhead or cottonmouth, for example |
| SNAKE | Copperhead, e.g. |
| SNAKE | Coral, for one |
| SNAKE | Crawling reptile |
| SNAKE | Creature devouring its own tail in the religious symbol ouroboros |
| SNAKE | Creature known for shedding its skin |
| SNAKE | Creature that grows longer in a classic video game (also in this puzzle, when it "eats" a black square) |
| SNAKE | Curl, meander |
| SNAKE | DJ ___ of "Lean On" |
| SNAKE | Dastardly sort |
| SNAKE | Deceitful sort |
| SNAKE | Double-crosser |
| SNAKE | Egyptian cobra, e.g. |
| SNAKE | Frequent lawbreaker on "The Simpsons" |
| SNAKE | Gem State stream |
| SNAKE | Hardy houseplant known for its upright leaves |
| SNAKE | Herpetology specimen |
| SNAKE | Herpetology subject |
| SNAKE | Hisser |
| SNAKE | Hisser that sheds its skin |
| SNAKE | Hissing reptile |
| SNAKE | Indy Jones' bugaboo |
| SNAKE | It has sliding scales |
| SNAKE | King cobra, for one |
| SNAKE | Krait or mamba |
| SNAKE | Like anaconda |
| SNAKE | Limbless reptile |
| SNAKE | Limbless, slithering reptile, some groups of which can sense infrared thermal radiation |
| SNAKE | Long thin reptile |
| SNAKE | Low character |
| SNAKE | Lowlife |
| SNAKE | Main character of the Metal Gear series |
| SNAKE | Mamba, boa, or python |
| SNAKE | Mamba, e.g. |
| SNAKE | Meander |
| SNAKE | Medusa hair make-up |
| SNAKE | Medusa's hair? |
| SNAKE | Member of a pit crew? |
| SNAKE | Mobile game named after a reptile, that was popularised by Nokia |
| SNAKE | Moccasin without laces |
| SNAKE | Moccasin, e.g. |
| SNAKE | Northwestern us river |
| SNAKE | No-good conniver |
| SNAKE | Ophidian |
| SNAKE | Ophidiophobe's fear |
| SNAKE | Ophiologist's specimen |
| SNAKE | Ouroboros reptile |
| SNAKE | Pet whose nickname might be Fang? |
| SNAKE | Pioneering video game in which you slither around and eat apples |
| SNAKE | Pipe cleaner |
| SNAKE | Plumber's device |
| SNAKE | Plumber's drain-clearing device |
| SNAKE | Plumber's gadget |
| SNAKE | Plumber's need |
| SNAKE | Plumber's pipe cleaner? |
| SNAKE | Plumber's tool |
| SNAKE | Plumber's tool to fix a clog |
| SNAKE | Plumber's tool used for unclogging a drain |
| SNAKE | Plumber's unclogger |
| SNAKE | Plumber’s favorite reptile? |
| SNAKE | Plumber’s tool |
| SNAKE | Plumbing gadget |
| SNAKE | Plumbing tool |
| SNAKE | Plunger alternative |
| SNAKE | Python |
| SNAKE | Python or anaconda |
| SNAKE | Python or anaconda, for example |
| SNAKE | Python or cobra |
| SNAKE | Python, cobra, or viper, for example |
| SNAKE | Rattler |
| SNAKE | Rattler or cobra |
| SNAKE | Rattler or python |
| SNAKE | Rattler, e.g. |
| SNAKE | Rattler, for one |
| SNAKE | Reptile associated with Slytherin House in the Harry Potter series |
| SNAKE | Reptile feared by an ophidiophobe |
| SNAKE | Reptile in the Chinese zodiac |
| SNAKE | Reptile not found in Iceland or Ireland |
| SNAKE | Reptile that dominates Taylor Swift's "Reputation" era imagery |
| SNAKE | Reptile that has no legs |
| SNAKE | Reptile that uses its forked tongue to smell |
| SNAKE | Reptile with a forked tongue |
| SNAKE | Reptile with no legs |
| SNAKE | River flowing from Yellowstone National Park |
| SNAKE | River flowing from Yellowstone National park |
| SNAKE | River that winds through three Western states |
| SNAKE | Scoundrel |
| SNAKE | See 25 Across |
| SNAKE | Serpent |
| SNAKE | Sir Hiss, in "Robin Hood," e.g. |
| SNAKE | Slithering reptile |
| SNAKE | Slithering reptile in the Chinese zodiac |
| SNAKE | Slithering reptile that hisses |
| SNAKE | Slithering reptile whose scales have inspired clothing prints in fashion |
| SNAKE | Slithering viper |
| SNAKE | Slithery reptile |
| SNAKE | Slithery reptile that may bite you |
| SNAKE | Sometimes venomous reptile |
| SNAKE | Treacherous one |
| SNAKE | Treacherous person |
| SNAKE | Treacherous person, ... in the grass |
| SNAKE | Treacherous sort |
| SNAKE | Treacherous type |
| SNAKE | Tributary of the Columbia |
| SNAKE | Twist and turn |
| SNAKE | Twisty reptile |
| SNAKE | Type not to be trusted |
| SNAKE | Unlaced moccasin |
| SNAKE | Venom carrier |
| SNAKE | Venomous reptile |
| SNAKE | Viper |
| SNAKE | Viper or Cobra |
| SNAKE | Viper or python, for example |
| SNAKE | Viper, for one |
| SNAKE | Weave in and out |
| SNAKE | What a charmer may charm |
| SNAKE | Wind |
| SNAKE | Wind this way and that |
| SNAKE | With 38-Across, hidden traitor |
| SNAKE | With 3- and 4-Down, treacherous person |
| SNAKE | With 9-Across, [•] [•] at a casino |
| SNAKE | Writhing creature |
| SNAKE | ___ Island, highly dangerous Brazilian island that is home to venomous golden lancehead vipers |
| SNAKE | ___ in the grass (faithless friend) |
| SNAKE | ___ oil (huckster's elixir) |
| SNAKE | — River, US watercourse forming part of the border between Idaho and Oregon |