| 100% | MELANIA | 7 | "___ and Me," 2020 book by Stephanie Winston Wolkoff about the author's friendship with the former first lady of the USA |
| 42% | MELANIA | 7 | “___ and Me,” book sourced in part from surreptitious recordings of conversations with the First Lady (September, 2020) |
| 38% | THIS | 4 | "___ I Remember," 1949 book by the former first lady of the US, Eleanor Roosevelt |
| 37% | HOUSE | 5 | "A White ___ Diary," 1970 book written by the former first lady of the US, Lady Bird Johnson |
| 37% | FULLYEARS | 9 | "Recollections of ___," 1914 book written by the former first lady of the US, Helen Herron Taft: 2 wds. |
| 33% | BECOMING | 8 | 2018 memoir written by the former first lady of the US, Michelle Obama |
| 33% | TIMES | 5 | "___ of My Life," 1978 book by the former first lady of the US, Betty Ford |
| 33% | OWN | 3 | "On My ___," 1958 book by the former first lady of the US, Eleanor Roosevelt |
| 33% | MICHELLEOBAMA | 13 | Former First Lady and "Becoming" author who was on the cover of the Winter 2021/22 issue of Vogue Knitting: 2 wds. |
| 32% | SOONG | 5 | ___ Mei-ling, former First Lady of China who was the TIME "Man and Wife of the Year" in 1937 along with her husband Chiang Kai-shek |
| 31% | MICHELLE | 8 | ___ Obama, former first lady of the United States who cameoed in an episode of "Parks and Recreation" |
| 31% | SHOUT | 5 | Author and journalist Philip Norman's first book which is considered a biography of The Beatles |
| 31% | RAIN | 4 | "___ On Me," song by Lady Gaga and Ariana Grande that won the MTV Video Music Award for Song of the Year in 2020 |
| 29% | MICHELLE | 8 | Obama, once First Lady of the USA |
| 29% | BRIGHTESTBLUE | 13 | 2020 album by 44-Across with the hit single "Worry About Me" (2 wds.) |
| 29% | LOVEFORSALE | 11 | 2021 collaborative album with the single "I Get a Kick Out of You" by Lady Gaga and 40-Across (3 wds.) |
| 29% | RAISA | 5 | ___ Gorbachev, former first lady of the Soviet Union |
| 29% | BARBARABUSH | 11 | First Lady of the United States (1989-1993) who wrote "Millie's Book": 2 wds. |
| 28% | EVAPERON | 8 | First lady of the 1940s and 1950s |
| 28% | EVAPERON | 8 | First Lady of the forties and fifties |
| 28% | IROBOT | 6 | Classic 1950 book with the line "It's your fiction that interests me. Your studies of the interplay of human motives and emotion" |
| 28% | TONI | 4 | First name of the most-selected author in Oprah's Book Club |
| 28% | PET | 3 | "What ___ Should I Get?," 2015 book by Dr. Seuss that chronicles the adventures of Jay and Kay |
| 28% | CARLA | 5 | Singer/model Bruni who is the former First Lady of France |
| 28% | BEACH | 5 | "Ghost ___," 1994 "Goosebumps" book by R.L. Stine about a pair of siblings and their encounters with ghosts |
| 28% | LEGALIZED | 9 | With 20 Across, what the people of AZ, NJ, MT, and SD voted for by proposition in 2020 |
| 28% | JACKIEKENNEDY | 13 | Former First Lady of the United States who was born in July (2 wds.) |
| 27% | PINACOLADA | 10 | What I'm going to have after I've finished writing these clues and it's spelled out with the first two letters of five of the longest puzzle answers |
| 27% | CAMNEWTON | 9 | Former Panthers quarterback and first overall draft pick in 2011 who signed with the Patriots in 2020: 2 wds. |
| 27% | PRINCESINTHE | 12 | & 9A The —, 1992 book by Alison Weir about Edward V and his brother Richard of Shrewsbury, Duke of York |