| 100% | HEMAN | 5 | "___ and the Masters of the Universe," popular animated series of the 1980s: Hyph. |
| 85% | HEMAN | 5 | "___ and the Masters of the Universe," popular animated cartoon series: Hyph. |
| 64% | MAN | 3 | "He-___ and the Masters of the Universe," animated series that ran from 1983 to 1985 |
| 54% | GHOSTBUSTERS | 12 | Popular animated series from the 1980s featuring Tracy the Gorilla and Ansa-Bone, a talking skull phone |
| 46% | SCOOBYDOO | 9 | The name of the Great Dane in the titular animated series, known for being able to speak and his love of eponymous snacks: Hyph. |
| 46% | SHE | 3 | "___-Ra and the Princesses of Power" (Netflix animated series) |
| 45% | XXXXXXXXXXX | 11 | Grammy-winning musician named for an animated TV series of the 1980s |
| 44% | TEENAGEMUTANT | 13 | "___ Ninja Turtles," popular animated series from the 1980s about characters named after Italian Renaissance artists: 2 wds. |
| 44% | SOAP | 4 | Billy Crystal comedy series of the 1970s and 1980s |
| 44% | JOE | 3 | "G.I. ___: A Real American Hero," popular animated series from the 1980s based on Hasbro's toy line |
| 44% | ICER | 4 | "He-Man and the Masters of the Universe" character who is Skeletor's northern agent, can freeze people and turn himself into water |
| 41% | SPACEBARONS | 11 | Masters of the Universe? |
| 41% | HEMAN | 5 | Masters of the Universe superhero |
| 41% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 41% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 42-Across (2 wds.) |
| 41% | JEM | 3 | "Truly outrageous" lead singer of the Holograms in a 1980s animated series |
| 40% | CIERA | 5 | Popular Oldsmobile model of the 1980s-'90s |
| 40% | DROIDS | 6 | "Star Wars: ___ - The Adventures of R2-D2 and C-3PO," 1985 animated TV series |
| 39% | SCTV | 4 | Canadian sketch comedy series of the 1970s and 1980s that featured Catherine O'Hara, John Candy, and Rick Moranis: Abbr. |
| 39% | RUGRATS | 7 | Animated series about Tommy Pickles and his friends which had a Halloween episode titled "Curse of the Werewuff" |
| 39% | TRANSFORMERS | 12 | "The ___," popular animated robot superhero series from the 1980s which was based on Hasbro's toy line |
| 39% | ETERNIA | 7 | Central planet in Masters of the Universe |
| 39% | CATCH | 5 | "Halt and ___ Fire," TV series set in the 1980s based on the revolution of personal computers |
| 39% | HEMAN | 5 | "Masters of the Universe" hero (Hyph.) |
| 39% | VHS | 3 | VCR format that was a popular mode of watching 19a in the 1980s and 1990s: Abbr. |
| 39% | SAILOR | 6 | "___ Moon," popular anime series released in 1992 which follows the journey of Usagi Tsukino and Luna |
| 38% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 38% | GEORGE | 6 | "___ of the Jungle," 1997 live-action film starring Brendan Fraser that is based on the popular animated series |
| 38% | AGE | 3 | "Kipo and the ___ of Wonderbeasts" (animated Netflix series) |
| 38% | IAMNOTAN | 8 | & 6D 2004 BBC TV animated comedy series featuring the voice talent of Steve Coogan and Amelia Bullmore |