| 100% | IGET | 4 | "___ by with a little help from my friends" (Beatles lyric): 2 wds. |
| 64% | JOECOCKER | 9 | British rock singer who covered "With a Little Help from My Friends" at 48-Across (2 wds.) |
| 61% | TRY | 3 | "Gonna ___ with a little help from my friends" |
| 61% | FRIENDS | 7 | Song by the Beatles: With a Little Help From My __ |
| 58% | MYFRIENDS | 9 | With a Little Help from __, by The Beatles |
| 57% | JOECOCKER | 9 | He got by with a little help from his friends |
| 57% | RINGO | 5 | "With a Little Help from My Friends" singer Starr |
| 57% | JOE | 3 | "With a Little Help from My Friends" singer Cocker |
| 57% | RINGO | 5 | "With a Little Help From My Friends" singer, familiarly |
| 57% | {COCK}ER | 8 | "With a Little Help From My Friends" singer Joe |
| 47% | TRY | 3 | Something to do with a little help from your friends |
| 39% | MURPHYBROWN | 11 | CBS TV character with a colorful last name, played by Candice Bergen from 1988 to 1998 and 2018 to 2019: 2 wds. |
| 37% | FINDINGDORY | 11 | 2016 Pixar sequel with a fish voiced by Ellen DeGeneres: 2 wds. |
| 35% | ONEUP | 5 | Outdo by a little: 2 wds. |
| 35% | MAITAI | 6 | Cocktail typically served with a little umbrella (2 wds.) |
| 35% | FAMILYGUY | 9 | Fox animated series with a mother named Lois (voiced by Alex Borstein): 2 wds. |
| 34% | MEREDITHGREY | 12 | ABC TV character with a colorful last name, played by Ellen Pompeo since 2005: 2 wds. |
| 34% | KIMKARDASHIAN | 13 | TV personality with a line of exercise videos called "Fit in Your Jeans by Friday": 2 wds. |
| 33% | ISEE | 4 | "___ a little silhouetto of a man" line from Bohemian Rhapsody (2 wds) |
| 33% | RACHELGREEN | 11 | NBC TV character with a colorful last name, played by Jennifer Aniston from 1994 to 2004: 2 wds. |
| 33% | ANDREABOCELLI | 13 | Opera singer with a law degree from the University of Pisa: 2 wds. |
| 32% | DIPINTO | 7 | Take a little bit from, as savings (2 wds.) |
| 32% | LETITBE | 7 | Last studio album from the Beatles that features a track by the same name: 3 wds. |
| 32% | LIKEAWOMAN | 10 | "Man! I Feel ___!" a country pop song with lyrics about female empowerment by Shania Twain: 3 wds. |
| 32% | ISPY | 4 | "___ with my little eye ... " (2 wds.) |
| 31% | LUCYINTHESKY | 12 | With 38-Across, a track from 15-Across, sung by Lennon, that faced several controversies about its initials: 4 wds. |
| 31% | RAPTURE | 7 | 1981 song by Blondie with lyrics about a man from Mars, who also features in the music video |
| 31% | ALOT | 4 | Not a little: 2 wds. |
| 31% | HEREWITHME | 10 | 2019 hit song by 17-Down featuring Chvrches with the lyrics "You're saying the words that I want you to say / There's a pain in my heart and it won't go away" (3 wds.) |
| 31% | ISPY | 4 | "___, with my little eye...": 2 wds. |