| 100% | RADIO | 5 | "___ Free Europe" (REM's first single) |
| 73% | REM | 3 | Alternative rock band whose first single was 1981's "Radio Free Europe" |
| 69% | REM | 3 | Band whose first single was "Radio Free Europe" |
| 48% | HEYJOE | 6 | Jimi Hendrix's first single |
| 47% | SOS | 3 | Rihanna's first #1 Billboard single |
| 47% | PIANOMAN | 8 | Billy Joel's first hit single |
| 45% | LOVESTORY | 9 | Taylor Swift's first single from Fearless album |
| 45% | SOS | 3 | Rihanna’s first No. 1 single |
| 45% | SIDEA | 5 | Single’s first half |
| 45% | LOVING | 6 | I've Been __ You, Elton John's first single |
| 44% | SOS | 3 | Rihanna's first #1 single |
| 44% | PEOPLE | 6 | Streisand's first hit single |
| 43% | BLACKOR | 7 | __ White; first single from MJ's Dangerous album |
| 42% | TITLETRACK | 10 | First single, often |
| 42% | TAKEITEASY | 10 | 1972 Eagles song that was the band's first single: 3 wds. |
| 41% | SPACEODDITY | 11 | David Bowie's first hit single (2 wds.) |
| 41% | SAVAGE | 6 | Megan Thee Stallion's first Billboard #1 single |
| 41% | APPLAUSE | 8 | First single from "ARTPOP" |
| 40% | RADIO | 5 | R.E.M.'s "___ Free Europe" |
| 40% | HAM | 3 | First single from Jay-Z and Kanye West's album "Watch the Throne" (2011) |
| 40% | LOVEMEDO | 8 | Beatles' first single |
| 39% | CRAZYINLOVE | 11 | 23-/38-Across's first #1 solo single: 3 wds. |
| 39% | SOS | 3 | Rihanna's first #1 single (out of 14 to date) |
| 39% | SEAL | 4 | Single-named singer whose first hit was 1990's "Crazy" |
| 39% | EMI | 3 | Producer of the Beatles' first single |
| 39% | LOVEMEDO | 8 | First single released by the Beatles |
| 39% | DDE | 3 | Pres. who served as NATO’s first Supreme Allied Commander Europe |
| 38% | TORN | 4 | First official single from LeToya's debut album released in 2006 |
| 38% | RAPPERSDELIGHT | 14 | First hip-hop single to enter Billboard's Top 40 chart |
| 38% | RIHANNA | 7 | Singer whose first #1 single was 2006's "SOS" |