| 100% | BARNEY | 6 | "___ Google and Snuffy Smith," the third-longest running American comics series which was first published in 1919 |
| 51% | TRACY | 5 | "Dick ___," one of the longest-running American comic strips which was first published in October 1931 |
| 49% | ALLEY | 5 | "Gasoline ___," longest-running American comic strip which was first published in November 1918 |
| 35% | THESIMPSONS | 11 | American animated sitcom which is running its 29th season making it the longest running TV series with 629 episodes: 2 wds. |
| 33% | GWENJORGENSEN | 13 | American distance runner and two-time ITU World Champion who was the first to win a triathlon gold for USA in the Olympics: 2 wds. |
| 30% | SCOTS | 5 | Language in which the first four cardinal numbers are ane, twa, three and fower |
| 30% | WATCHMEN | 8 | Comic book maxiseries published by DC Comics and is set in an alternate reality in the '80s |
| 30% | FIRESAFETY | 10 | Subject in which the first words of 17-, 29- and 46-Across are sage advice |
| 30% | SAMOAN | 6 | Language in which the first six counting numbers are tasi, lua, tolu, fa, lima and ono |
| 29% | ANNPRESTON | 10 | American physician and activist who was the first female dean of a medical school in the world: 2 wds. |
| 29% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 29% | BATMOBILE | 9 | The Dark Knight's car which heavily featured in the animated series and is filled with his trademark gadgets and weaponry |
| 28% | FINDMEGUILTY | 12 | Comedy drama crime film starring Peter Dinklage which is based on a true story of the longest Mafia trial in American history: 3 wds. |
| 28% | JORDANSPIETH | 12 | American golfer who won the 2017 Open Championship and was runner-up to 49-Across in the 2021 Open Championship (2 wds.) |
| 28% | SINCLAIRLEWIS | 13 | Minnesota novelist and short story writer who was the first American honored with the Nobel Prize in Literature (2 wds.) |
| 28% | JACKIE | 6 | Some call her the First Lady of American athletics and has won several Olympic medals in heptathlon and long jump |
| 28% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 28% | TATER | 5 | Son of Snuffy Smith, in the comics |
| 28% | TANK | 4 | "Shark ___," business reality TV series which is the American franchise of 4a |
| 28% | ASYOULIKEIT | 11 | William Shakespeare play first published in 1623 featuring the characters Celia and Rosalind |
| 28% | JEREMYPENA | 10 | 33-Across shortstop who was named MVP of both the American League Championship Series and the World Series in 2022 (2 wds.) |
| 27% | WATCHMEN | 8 | American satirical and dystopian superhero film directed by Zack Snyder which is based on a DC Comics limited series of the same name |
| 27% | TERRY | 5 | "___ and the Pirates," adventure comic strip by Milton Caniff which follows a young American boy in China |
| 27% | SMORE | 5 | The first recipe for one was published in "Tramping and Trailing With the Girl Scouts" (1927) |
| 27% | ADOLF | 5 | First name from which the "Adi" in Adidas is derived |
| 27% | SHEPARD | 7 | Alan who was the first American in space |
| 27% | SALLYRIDE | 9 | She was the first American woman in Space |
| 26% | THREE | 5 | *Number of Charlie's Angels which is also the first digit in Pi |
| 26% | GUARINI | 7 | Justin, who was the first American Idol runner-up |
| 26% | GEARS | 5 | What first, second, and third are, in a car |