| 100% | LIFE | 4 | "___ in Pieces" (CBS sitcom starring Dianne Wiest and James Brolin) |
| 44% | LIFEINPIECES | 12 | 2015-2019 CBS sitcom in which Dianne Wiest played Dr. Joan Short: 3 wds. |
| 40% | COOKIE | 6 | 1989 film written by Nora Ephron starring Dianne Wiest and Peter Falk |
| 40% | MOM | 3 | CBS sitcom starring Allison Janney and Anna Faris |
| 40% | MOM | 3 | CBS sitcom starring Anna Faris and Allison Janney |
| 36% | MASON | 5 | James who starred in Lolita and Bigger Than Life |
| 36% | SUDDENLYSUSAN | 13 | Sitcom starring 15-Across and 32-Across that premiered in 1996 (2 wds.) |
| 35% | JUSTSHOOTME | 11 | Sitcom starring David Spade that debuted in 1997 and ran for seven seasons (3 wds.) |
| 35% | CAPRICORNONE | 12 | 1977 film thriller starring Elliott Gould and James Brolin |
| 35% | TVCAMERA | 8 | What sitcom stars and reporters stand in front of to be recorded: 2 wds. |
| 34% | THEUNICORN | 10 | CBS sitcom starring 18-Across and 33-Across about a recently widowed father who re-enters the dating scene (2 wds.) |
| 34% | MOM | 3 | CBS sitcom starring Allison Janney |
| 34% | MOM | 3 | CBS sitcom starring Anna Faris |
| 33% | SPINCITY | 8 | Political sitcom starring Barry Bostwick, 15-Across, 20-Across, and 37-Across that debuted in 1996 (2 wds.) |
| 33% | ROSEANNEBARR | 12 | Former sitcom star who ran for president in 2012 on the Peace and Freedom Party ticket: 2 wds. |
| 33% | THEMIDDLE | 9 | ABC sitcom starring 16-Across and 33-Across in its ninth and final season (2 wds.) |
| 32% | THEBRADYBUNCH | 13 | Family sitcom starring Robert Reed and Florence Henderson that debuted in 1969 (3 wds.) |
| 32% | MEDICALCENTER | 13 | Hospital drama starring James Daly and Chad Everett that debuted in 1969 (2 wds.) |
| 32% | DAY | 3 | Simon —, actor-comedian who co-wrote and starred in 2003 BBC TV sitcom Grass |
| 32% | MOM | 3 | Current CBS sitcom starring Anna Faris |
| 32% | ALLINTHEFAMILY | 14 | Norman Lear sitcom starring 16-Across and 35-Across that debuted in January 1971 (4 wds.) |
| 32% | ETHELMERMAN | 11 | ... and 99-Across starred in musicals and share their first names with a classic sitcom couple |
| 32% | THEKINGOF | 9 | With 19-Across, Kevin James sitcom with two chess pieces in its name: 3 wds. |
| 32% | DAY | 3 | Simon —, actor and comedian who co-wrote and starred in 2003 BBC TV sitcom Grass |
| 32% | RHODA | 5 | Mary's best friend on the CBS sitcom "The Mary Tyler Moore Show" starring Mary Tyler Moore and Valerie Harper |
| 31% | SUPERSTORE | 10 | NBC sitcom starring 18-Across and 24-Across/36-Across set in a St. Louis big-box retailer |
| 31% | MOM | 3 | Eight-season CBS sitcom starring Allison Janney |
| 31% | ARNESS | 6 | 6 ft 7 in James, star of "Gunsmoke" which ran for 20 years (1955-75) on CBS |
| 31% | MAYNARD | 7 | Bill —, actor-comedian who starred in ITV sitcoms Oh No, It's Selwyn Froggitt! and The Gaffer |