| 100% | NEW | 3 | "___ Moon" (second "Twilight" novel) |
| 69% | NEWMOON | 7 | Second novel in "The Twilight Saga" which was released as a movie in 2009: 2 wds. |
| 67% | NEWMOON | 7 | Second novel in the "Twilight" series (2 wds.) |
| 63% | OMOO | 4 | Melville's second novel |
| 58% | RHEA | 4 | Second-largest moon of Saturn |
| 58% | BUZZALDRIN | 10 | Second man on the moon |
| 58% | OBERON | 6 | Second-largest moon of Uranus |
| 58% | CALLISTO | 8 | Second largest moon of Jupiter |
| 58% | ALDRIN | 6 | Second man on the moon |
| 56% | SEE | 3 | Second word of "Bad Moon Rising" |
| 56% | NEW | 3 | "The Twilight Saga: ___ Moon" |
| 56% | SAGA | 4 | "The Twilight ___: New Moon" |
| 55% | ALDRIN | 6 | Second man to walk on the moon |
| 55% | TITAN | 5 | Second-largest moon in the solar system |
| 55% | ALDRIN | 6 | Second person to walk on the moon |
| 55% | TITAN | 5 | Second largest moon in our solar system |
| 54% | RHEA | 4 | Saturn's second-largest moon |
| 54% | OMOO | 4 | Herman Melville's second novel |
| 54% | SULA | 4 | Toni Morrison's second novel |
| 54% | NEW | 3 | "___ Moon" (second book in Stephenie Meyer's "Twilight" series) |
| 53% | ALDRIN | 6 | Second man to walk on the moon Buzz ___ |
| 53% | BUZZALDRIN | 10 | Second man to set foot on the moon |
| 53% | THECOLLECTORS | 13 | Second novel featuring the Camel Club (2 wds.) |
| 53% | SAGA | 4 | "The Twilight ___: New Moon" (2009 film) |
| 53% | FIRM | 4 | "The ___" (John Grisham's second novel) |
| 53% | BELAMI | 6 | Guy de Maupassant's second novel |
| 53% | SALEMS | 6 | "___ Lot" (Stephen King's second novel) |
| 52% | BUZZALDRIN | 10 | Second astronaut to walk on the moon: 2 wds. |
| 52% | TITAN | 5 | Second-largest moon in the solar system, after Ganymede |
| 52% | WRONGFULDEATH | 13 | Second David Sloane novel by Robert Dugoni (2 wds.) |