| 100% | IREST | 5 | "___ perplexed with a thousand cares": Shak. |
| 45% | HERO | 4 | Joseph Campbell's "The ___ with a Thousand Faces" |
| 45% | NARY | 4 | With ___ a care (untroubled) |
| 43% | EPIC | 4 | Movie with a cast of thousands |
| 43% | EPIC | 4 | Film with a cast of thousands |
| 42% | EPIC | 4 | Movie with a cast of thousands, perhaps |
| 41% | KILO | 4 | Metric system prefix with a multiplier of one thousand |
| 41% | EPIC | 4 | Larger than life movie with a cast of thousands |
| 41% | BRITA | 5 | Brand with a “Drink like you care” ad campaign |
| 41% | SENSITIVELY | 11 | With care to a person's feelings |
| 40% | ROLEX | 5 | Accessory with a starting price of over five thousand dollars |
| 40% | OLAY | 4 | A skin care brand with the tagline "Ageless" |
| 39% | TEND | 4 | Care for, as a bonsai tree (rhymes with "mend") |
| 39% | AMA | 3 | Org. with a Health Care Advocacy web page |
| 38% | EASEBY | 6 | Pass with care, as a fellow bus passenger |
| 38% | BEWARETHE | 9 | With 22-Across, a timely warning from "Julius Caesar" by Shak. |
| 37% | ACID | 4 | It should be handled with care in a lab |
| 36% | IAMS | 4 | Cat food brand with a Hairball Care product |
| 36% | AVEDA | 5 | Skin care brand with a Nutriplenish line |
| 36% | AVEDA | 5 | Skin care company with a Sanskrit name |
| 35% | NIVEA | 5 | Skin care brand with a "For Men" line |
| 35% | OLAY | 4 | Skin care brand with a Fresh Effects line |
| 35% | OLAY | 4 | Skin care brand with a Total Effects line |
| 35% | OLAY | 4 | Skin care brand with a Daily Facials line |
| 35% | AETNA | 5 | Health care giant with a violet heart logo |
| 35% | OLAY | 4 | Skin care company with a Retinol 24 line |
| 35% | PANTENE | 7 | Hair care brand with a Miracle Rescue line |
| 35% | DOVE | 4 | Personal care brand with a "peaceful" bird logo |
| 35% | ROC | 3 | Skin care brand with a Retinol Correxion line |
| 35% | EM{OR}Y | 7 | Georgia university with a large health-care system |