| 100% | COURAGE | 7 | "___ the Cowardly Dog," 1999 Cartoon Network animated series with a dog as the main character |
| 64% | RIN | 3 | "The Adventures of ___ Tin Tin," 1954 television series with a dog as the main character |
| 55% | BUSH | 4 | "Skippy the ___ Kangaroo," Australian TV series with a kangaroo as the main character |
| 53% | BLOG | 4 | "Dog with a ___," 2012 Disney television series with a dog as the main character |
| 51% | PAW | 3 | "___ Patrol," Canadian animated TV series with animals as the main characters that was made into a feature movie |
| 41% | STEVENUNIVERSE | 14 | Cartoon Network animated series that featured Susan Egan as the voice of the Crystal Gems' former leader Rose Quartz (2 wds.) |
| 40% | ADVENTURETIME | 13 | Award-winning Cartoon Network series with Finn the Human and Jake the Dog |
| 39% | SEARCHPARTY | 11 | HBO Max series that opened with the main characters investigating the disappearance of a college friend: 2 wds. |
| 37% | JOHNNYBRAVO | 11 | Popular animated TV series with a boorish, muscular young man as its titular character who tries to get women to date him: 2 wds. |
| 36% | ANTZ | 4 | 1998 animated film with a character named Chip the Wasp |
| 36% | SCOOBYDOO | 9 | Animated series about mystery-solving with a dog |
| 36% | SIMPSONS | 8 | "The ___," animated TV series by Matt Groening, with a crossover episode featuring "The X-Files" characters |
| 35% | COURAGE | 7 | "___ the Cowardly Dog" (Cartoon Network show) |
| 35% | KIPPER | 6 | Low stimulation and toddler-friendly British animated series with an eponymous warm-hearted dog character |
| 35% | CINDERELLA | 10 | 2015 movie version of a classic fairy tale, with 15-Across as the title character |
| 34% | CAT | 3 | "The ___ in the Hat," 2003 film with a feline pet as the main character which can be found in the movies at 33a, 43a, 46a, 4d, and 8d |
| 34% | KIPOANDTHEAGE | 13 | With 32-Across, animated series about a girl from beneath the Earth's surface: 4 wds. |
| 34% | ADVENTURETIME | 13 | Animated Cartoon Network series set in the Land of Ooo: 2 wds. |
| 33% | CARMENSANDIEGO | 14 | Netflix animated adventure series featuring the voice of 49-Across as the title character (2 wds.) |
| 33% | AQUATEEN | 8 | Any of three title characters in a long-running Cartoon Network series |
| 33% | JOHNNYBRAVO | 11 | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| 33% | HITMONKEY | 9 | Animated series on Hulu with Jason Sudeikis as a Japanese macaque's ghostly mentor: Hyph. |
| 33% | GREGHEFFLEY | 11 | Main character of the "Diary of a Wimpy Kid" series by Jeff Kinney (2 wds.) |
| 33% | BOJACKHORSEMAN | 14 | Show with the characters Mr. Peanutbutter, a dog, and Sextina Aquafina, a dolphin |
| 33% | IRONGIANT | 9 | 1999 animated tearjerker based on a Ted Hughes story, with The |
| 33% | RAJ | 3 | "The Big Bang Theory" character with a dog named Cinnamon |
| 33% | LOCKE | 5 | "Lost" character with the same name as a philosopher |
| 33% | OSWALD | 6 | Animated octopus with a dog named Weenie |
| 33% | MAGGIESIMPSON | 13 | Cartoon character with a blue hair bow whose long-running series debuted in 1989 (2 wds.) |
| 32% | MANDALORIAN | 11 | "The ___," TV series featuring Jon Favreau as a voice actor for the character Paz Vizsla |