| 100% | NOAH | 4 | "21 Lessons for the 21st Century" author Yuval ___ Harari |
| 46% | CIRQUE | 6 | __ du soleil, traveling show for the 21st century |
| 36% | LORDE | 5 | "The 21st century's author of adolescent evolution," per Cyrena Touros |
| 35% | UPDATE | 6 | Bring into the 21st century |
| 35% | MMI | 3 | Start of the 21st century |
| 34% | OBAMACRAT | 9 | Certain liberal of the 21st century |
| 33% | ALPHA | 5 | Generation ___, first to be born in the 21st century |
| 33% | TIMOR | 5 | __-Leste: first new sovereign state of the 21st century |
| 32% | DATASCIENTIST | 13 | "Sexiest job of the 21st century," per Harvard Business Review |
| 32% | BROKEBACKMOUNTAIN | 17 | Couple in the 21st century with Best Director Oscar winners |
| 32% | PRINTSHOP | 9 | Early venture for the 21-Acrosses |
| 31% | TWERKINGCLASS | 13 | Lessons for those who got behind in the dancing? |
| 31% | ALOE | 4 | American ___ (another name for the century plant) |
| 31% | EBERT | 5 | "Questions for the Movie Answer Man" author |
| 31% | UTA | 3 | A Challenge for the Actor author Hagen |
| 31% | SAMUELALITO | 11 | Second Supreme Court justice confirmed in the 21st century (2006): 2 wds. |
| 31% | SONIASOTOMAYOR | 14 | Third Supreme Court justice confirmed in the 21st century (2009): 2 wds. |
| 31% | JOHNROBERTS | 11 | First Supreme Court justice confirmed in the 21st century (2005): 2 wds. |
| 31% | EDUCATION | 9 | Central issue for the author of 15-Across |
| 31% | BEV | 3 | Abbreviation for the first name of author Cleary |
| 31% | POWEREDFLIGHT | 13 | Famous Dec. 17 venture for the 21-Acrosses |
| 31% | HEYDAY | 6 | The early 20th century, for vaudeville |
| 31% | EWEN | 4 | "Music for the Millions" author David |
| 31% | DESSEN | 6 | "Along for the Ride" author Sarah |
| 30% | EBIKE | 5 | Type of bicycle popularized in the 21st century that has rechargeable batteries: Hyph. |
| 30% | OUGHTS | 6 | Possible name for the first decade of the century |
| 30% | ALTON | 5 | “I’m Just Here for the Food” author Brown |
| 30% | NOREASTER | 9 | The "storm of the century," for one |
| 30% | WENDT | 5 | "Sons for the Return Home" author Albert |
| 30% | NOAM | 4 | "Requiem for the American Dream" author Chomsky |