| 100% | EVAGREEN | 8 | "300: Rise of an Empire" actress who played Vanessa Ives on 21-Across: 2 wds. |
| 49% | TOKSOLAGUNDOYE | 14 | Actress who plays the head of an Ivy League psychology department on "Frasier" (2 wds.) |
| 47% | TIFFANYHADDISH | 14 | "The Freak Brothers" voice actress who plays Vanessa on 44-Across (2 wds.) |
| 46% | BARBARAEDEN | 11 | Actress who played Jeannie on "I Dream of Jeannie": 2 wds. |
| 46% | LISAWHELCHEL | 12 | Actress who played Blair on "The Facts of Life": 2 wds. |
| 46% | KIMFIELDS | 9 | Actress who played Tootie on "The Facts of Life": 2 wds. |
| 46% | MINDYCOHN | 9 | Actress who played Natalie on "The Facts of Life": 2 wds. |
| 46% | CATHERINEOHARA | 14 | "Beetlejuice" actress who plays actress Moira Rose on 19-Across: 2 wds. |
| 46% | CHARLOTTERAE | 12 | Actress who played Mrs. Garrett on "The Facts of Life": 2 wds. |
| 45% | ROBINWRIGHT | 11 | "The Princess Bride" actress who played President Claire Underwood on "House of Cards": 2 wds. |
| 45% | AMANDASEYFRIED | 14 | "The Dropout" actress who plays an interrogator on "The Crowded Room": 2 wds. |
| 45% | BARBARAFELDON | 13 | Actress who played Agent 99 on 16-Across: 2 wds. |
| 45% | DANIELLEFISHEL | 14 | Actress who plays Topanga Matthews on 33-Across: 2 wds. |
| 45% | OLIVIACOLMAN | 12 | Actress who played Queen Elizabeth II on two seasons of Netflix's "The Crown": 2 wds. |
| 45% | DANADELANY | 10 | "China Beach" actress who played a medical examiner on "Body of Proof": 2 wds. |
| 44% | LAURENBACALL | 12 | "Key Largo" actress who played an American widow in "Murder on the Orient Express": 2 wds. |
| 44% | HILARYSWANK | 11 | "Amelia" actress who plays an astronaut heading to Mars on the Netflix series "Away": 2 wds. |
| 44% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 43% | ANNAFARIS | 9 | Actress who played Christy Plunkett on the first seven seasons of the CBS sitcom "Mom": 2 wds. |
| 43% | JURNEESMOLLETT | 14 | "Birds of Prey" actress who plays Leti Lewis on "Lovecraft Country": 2 wds. |
| 43% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 43% | ALEXISBLEDEL | 12 | "The Sisterhood of the Traveling Pants" actress who played daughter Rory on 14-Across: 2 wds. |
| 43% | VIOLADAVIS | 10 | Actress who won a Tony and an Oscar for playing Rose Maxson in "Fences": 2 wds. |
| 43% | SARAHCHALKE | 11 | "Scrubs" actress who plays Kate Mularkey on the Netflix adaptation of 41-Across (2 wds.) |
| 43% | NATALIEDORMER | 13 | "Game of Thrones" actress who played 32-Across on the CBS series "Elementary" (2 wds.) |
| 43% | CHRISTINARICCI | 14 | "Z: The Beginning of Everything" actress who plays adult Misty on 50-Across (2 wds.) |
| 43% | TEALEONI | 8 | Actress who plays Secretary of State Elizabeth McCord on "Madam Secretary" (2 wds.) |
| 42% | LAURENGRAHAM | 12 | "Parenthood" actress who played mother Lorelai on 14-Across: 2 wds. |
| 42% | SARAHCHALKE | 11 | "Scrubs" actress who plays Kate Mularkey on 19-Across: 2 wds. |
| 42% | KATHERINEHEIGL | 14 | "Suits" actress who plays Tully Hart on 19-Across: 2 wds. |