| 100% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 68% | ADAMSANDLER | 11 | "Grown Ups" actor who won the Mark Twain Prize in 2023: 2 wds. |
| 62% | EDDIEMURPHY | 11 | "The Nutty Professor" actor and "SNL" star who won the Mark Twain Prize for American Humor in 2015: 2 wds. |
| 62% | WILLFERRELL | 11 | "Elf" actor and "Saturday Night Live" star who won the Mark Twain Prize for American Humor in 2011: 2 wds. |
| 61% | STEVEMARTIN | 11 | "Father of the Bride" actor who won the Mark Twain Prize for American Humor in 2005: 2 wds. |
| 59% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who plays Usnavi, the lead character in 18-Across: 2 wds. |
| 59% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 59% | TINAFEY | 7 | "30 Rock" star who was awarded the Mark Twain Prize in 2010: 2 wds. |
| 57% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who played Reggie Warrington in "The Nutty Professor": 2 wds. |
| 54% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who played Philip Hamilton in "Hamilton": 2 wds. |
| 54% | BRADLEYCOOPER | 13 | "A Star Is Born" actor who plays Leonard Bernstein in "Maestro": 2 wds. |
| 53% | BRADLEYCOOPER | 13 | Actor who had a song from "A Star Is Born" chart on the Billboard Hot 100 in 2018: 2 wds. |
| 53% | CHRISTIANBALE | 13 | Actor who won the 2019 Golden Globe Award for Best Actor in a Motion Picture - Musical or Comedy, for the film "Vice": 2 wds. |
| 52% | JAYLENO | 7 | Former "Tonight Show" host who was awarded the Mark Twain Prize in 2014: 2 wds. |
| 51% | CAROLBURNETT | 12 | Comedian and variety show host who was awarded the Mark Twain Prize in 2013: 2 wds. |
| 51% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 51% | JEREMYSTRONG | 12 | "Succession" star who won the 2020 Emmy for Outstanding Lead Actor in a Drama Series: 2 wds. |
| 50% | BRYANCRANSTON | 13 | "Network" actor who won the Tony Award for Best Performance by a Leading Actor in a Play in 2019 (2 wds.) |
| 50% | DONALDGLOVER | 12 | Actor who won the Emmy for Outstanding Lead Actor in a Comedy for "Atlanta": 2 wds. |
| 49% | LENO | 4 | Late-night host who won the Mark Twain Prize in 2014 |
| 49% | BRADLEYCOOPER | 13 | "American Sniper" actor who directed and stars in the "A Star Is Born" remake: 2 wds. |
| 48% | EUGENELEVY | 10 | "Schitt's Creek" star who won the 2020 Emmy for Outstanding Lead Actor in a Comedy Series: 2 wds. |
| 48% | JASONSUDEIKIS | 13 | "Ted Lasso" actor who won the 2021 Emmy for Outstanding Lead Actor in a Comedy Series: 2 wds. |
| 48% | JHARRELJEROME | 13 | Actor who won a 2019 Emmy for his role in "When They See Us": 2 wds. |
| 48% | GERALDMCRANEY | 13 | Actor who won the 2017 Emmy for Outstanding Guest Actor in a Drama Series for playing the obstetrician who delivered Kevin and Kate in NBC's "This Is Us" (2 wds.) |
| 48% | JOSHOCONNOR | 11 | "The Crown" actor who won the 2021 Emmy for Outstanding Lead Actor in a Drama Series: 2 wds. |
| 47% | CARROLLOCONNOR | 14 | Actor who starred on "All in the Family," a Norman Lear sitcom: 2 wds. |
| 47% | LENO | 4 | Jay who won the Mark Twain Prize for American Humor in 2014 |
| 47% | JEREMYSTRONG | 12 | "Succession" actor who won the 2024 Best Leading Actor in a Play Tony for "An Enemy of the People": 2 wds. |
| 47% | JONATHANGROFF | 13 | "Frozen" voice actor who won the 2024 Best Leading Actor in a Musical Tony for "Merrily We Roll Along": 2 wds. |