| 100% | JESSICALANGE | 12 | "A Thousand Acres" actress who plays Dorothy Cavendish in "Marlowe" (2 wds.) |
| 61% | LEAMICHELE | 10 | "Glee" actress who plays Dorothy in "Legends of Oz": 2 wds. |
| 60% | MARGOTROBBIE | 12 | Actress who plays a fictional associate producer in "Bombshell": 2 wds. |
| 59% | TESSATHOMPSON | 13 | "Thor: Ragnarok" actress who plays a surveyor in "Annihilation": 2 wds. |
| 59% | NATALIEPORTMAN | 14 | "Black Swan" actress who plays a biologist in "Annihilation": 2 wds. |
| 59% | AUBREYPLAZA | 11 | Actress who plays a profane 14th-century nun in "The Little Hours": 2 wds. |
| 59% | GRACEKELLY | 10 | Actress who played a socialite in Hitchcock's "Dial M for Murder": 2 wds. |
| 59% | KATHYBATES | 10 | Actress who plays a marijuana dispensary owner in the new Netflix comedy "Disjointed": 2 wds. |
| 58% | MARISATOMEI | 11 | "My Cousin Vinny" actress who plays a teacher in "Spare Parts": 2 wds. |
| 58% | CAREYMULLIGAN | 13 | "The Great Gatsby" actress who plays a feminist in 42-Across: 2 wds. |
| 58% | MERYLSTREEP | 11 | "Into the Woods" actress who plays a feminist in 42-Across: 2 wds. |
| 58% | VIOLADAVIS | 10 | "Fences" actress who plays a government official in "The Suicide Squad": 2 wds. |
| 58% | JERYLPRESCOTT | 13 | Actress who plays Madame Xanadu, a blind fortune teller, in the show in 18a: 2 wds. |
| 58% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who plays a police officer in "Superior Donuts": 2 wds. |
| 58% | DIANNEWIEST | 11 | "Bullets Over Broadway" actress who plays a grandma on "Life in Pieces": 2 wds. |
| 58% | ALICEBRAGA | 10 | "The New Mutants" actress who plays a revolutionary in "The Suicide Squad": 2 wds. |
| 58% | SANDRABULLOCK | 13 | "The Blind Side" actress who played a crossword constructor in 33-Across: 2 wds. |
| 58% | KRISTENSTEWART | 14 | Actress who played a vampire in 2012's "The Twilight Saga: Breaking Dawn — Part 2": 2 wds. |
| 58% | DEBRAMESSING | 12 | Actress who played 17a in the series for which she won a Primetime Emmy Award: 2 wds. |
| 57% | MARYMCDONNELL | 13 | "Independence Day" actress who played Stands With a Fist in "Dances With Wolves": 2 wds. |
| 57% | INGRIDBERGMAN | 13 | "Casablanca" actress who played a Swedish missionary in "Murder on the Orient Express": 2 wds. |
| 57% | ANYATAYLORJOY | 13 | "Glass" actress who played 19-Across in a 2020 film: 2 wds., hyph. |
| 57% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 57% | HELENMIRREN | 11 | "The Queen" actress who plays a retired intelligence agent in "The Thursday Murder Club": 2 wds. |
| 57% | FARRAHFAWCETT | 13 | "Charlie's Angels" actress who played a photographer nicknamed Beauty in "The Cannonball Run": 2 wds. |
| 57% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 57% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 57% | CAMERONDIAZ | 11 | "The Mask" actress who played a private investigator named Natalie in "Charlie's Angels": 2 wds. |
| 57% | ZOESALDANA | 10 | Actress who has played Gamora, a green superwoman in various Marvel movies: 2 wds. |
| 57% | DIANEKEATON | 11 | Actress who plays a mother in "Father of the Bride" (2 wds.) |