| 100% | MINDYKALING | 11 | "A Wrinkle in Time" actress who plays new writer Molly Patel in "Late Night" (2 wds.) |
| 58% | STORMREID | 9 | "A Wrinkle in Time" actress who plays Jack Radcliff's niece in 35-Across (2 wds.) |
| 57% | MINDYKALING | 11 | "A Wrinkle in Time" actress who plays Amita in "Ocean's 8" (2 wds.) |
| 56% | MINDYKALING | 11 | Actress who plays Mrs. Who in "A Wrinkle in Time" (2 wds.) |
| 56% | OPRAHWINFREY | 12 | Actress who plays Mrs. Which in "A Wrinkle in Time" (2 wds.) |
| 54% | KATHYBATES | 10 | Actress who plays a marijuana dispensary owner in the new Netflix comedy "Disjointed": 2 wds. |
| 53% | ANDIEMACDOWELL | 14 | "Four Weddings and a Funeral" actress who plays news producer Rita Hanson in 44-Across (2 wds.) |
| 52% | ALICEBRAGA | 10 | "The New Mutants" actress who plays a revolutionary in "The Suicide Squad": 2 wds. |
| 52% | STORMREID | 9 | Actress playing Meg Murry in "A Wrinkle in Time": 2 wds. |
| 52% | OPRAHWINFREY | 12 | Actress playing Mrs. Which in "A Wrinkle in Time": 2 wds. |
| 52% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 51% | KIRSTENDUNST | 12 | "The Power of the Dog" actress who plays a journalist in the new movie "Civil War": 2 wds. |
| 50% | NATASHALYONNE | 13 | "Russian Doll" actress who co-constructed a New York Times crossword in 2019: 2 wds. |
| 50% | MARGOTROBBIE | 12 | "Once Upon a Time in Hollywood" actress who plays Kayla Pospisil in "Bombshell" (2 wds.) |
| 49% | MARGOTROBBIE | 12 | Actress who plays a fictional associate producer in "Bombshell": 2 wds. |
| 49% | HAYLEYATWELL | 12 | Actress who plays Grace in the new "Mission: Impossible" movie: 2 wds. |
| 49% | PATTYDUKE | 9 | Late actress who played identical cousins on a 1960s sitcom: 2 wds. |
| 48% | ANYATAYLORJOY | 13 | "Split" actress who plays Magik in "The New Mutants": 2 wds., hyph. |
| 48% | MAISIEWILLIAMS | 14 | "Game of Thrones" actress who plays Wolfsbane in "The New Mutants": 2 wds. |
| 48% | JENNIFERHUDSON | 14 | "Dreamgirls" actress who plays Aretha Franklin in the new movie "Respect": 2 wds. |
| 48% | CYBILLSHEPHERD | 14 | "Moonlighting" actress who played Jacy Farrow in "The Last Picture Show": 2 wds. |
| 48% | MARISATOMEI | 11 | "My Cousin Vinny" actress who plays a teacher in "Spare Parts": 2 wds. |
| 48% | VIOLADAVIS | 10 | "Fences" actress who plays a government official in "The Suicide Squad": 2 wds. |
| 48% | EMMATHOMPSON | 12 | "Love Actually" actress who plays veteran late-night talk show host Katherine Newbury in "Late Night" (2 wds.) |
| 48% | HELENMIRREN | 11 | "The Queen" actress who plays a retired intelligence agent in "The Thursday Murder Club": 2 wds. |
| 48% | FARRAHFAWCETT | 13 | "Charlie's Angels" actress who played a photographer nicknamed Beauty in "The Cannonball Run": 2 wds. |
| 47% | FLORENCEPUGH | 12 | "Little Women" actress who plays Jean Tatlock in the new film "Oppenheimer": 2 wds. |
| 47% | GWYNETHPALTROW | 14 | "Shakespeare in Love" actress who played 19-Across in a 1996 film: 2 wds. |
| 47% | DIANNEWIEST | 11 | "Bullets Over Broadway" actress who plays a grandma on "Life in Pieces": 2 wds. |
| 47% | XOCHITLGOMEZ | 12 | "The Baby-Sitters Club" actress who plays a time-traveling teenager in "Doctor Strange in the Multiverse of Madness" (2 wds.) |