| 100% | JOHNDIMAGGIO | 12 | "Adventure Time" voice actor who voices Bender on "Futurama" (2 wds.) |
| 71% | JOHNDIMAGGIO | 12 | Actor who voices the robot Bender on "Futurama" (2 wds.) |
| 62% | HARRYSHEARER | 12 | Actor who voices Principal Seymour Skinner on "The Simpsons": 2 wds. |
| 62% | SETHGREEN | 9 | Actor who voices Chris Griffin on "Family Guy": 2 wds. |
| 62% | ISAACHAYES | 10 | Actor/singer who voiced Chef on "South Park": 2 wds. |
| 61% | CHRISPARNELL | 12 | Former "SNL" actor who voices Cyril Figgis on "Archer": 2 wds. |
| 61% | RONFUNCHES | 10 | "Undateable" actor who voices King Shark on "Harley Quinn": 2 wds. |
| 61% | TONYHALE | 8 | "Veep" actor who voices Doctor Psycho on "Harley Quinn": 2 wds. |
| 59% | TREYPARKER | 10 | "BASEketball" actor who voices teacher Herbert Garrison on "South Park": 2 wds. |
| 59% | PATTONOSWALT | 12 | "Ratatouille" actor who voices Matthew the Raven on "The Sandman": 2 wds. |
| 59% | BENFELDMAN | 10 | "Superstore" actor who voices Avi Schwooper on "Long Story Short": 2 wds. |
| 59% | BOBBYMOYNIHAN | 13 | Comedy actor who voices Panda on "We Bare Bears" (2 wds.) |
| 58% | RAINNWILSON | 11 | "Monsters vs. Aliens" voice actor who played Dwight Schrute on "The Office": 2 wds |
| 58% | ROBERTCARLYLE | 13 | "The Full Monty" actor who plays Rumplestiltskin on "Once Upon a Time": 2 wds. |
| 58% | JOHNAMOS | 8 | Actor who starred on "Good Times," a Norman Lear sitcom: 2 wds. |
| 58% | ADAMWEST | 8 | "Batman" actor who voices himself on 45-Across (2 wds.) |
| 58% | JERRYOCONNELL | 13 | "Sliders" actor who voices first officer Jack Ransom on "Star Trek: Lower Decks": 2 wds. |
| 58% | JACKQUAID | 9 | "The Boys" actor who voices ensign Brad Boimler on "Star Trek: Lower Decks": 2 wds. |
| 57% | CHANCEPERDOMO | 13 | "Chilling Adventures of Sabrina" actor who plays Andre Anderson on "Gen V": 2 wds. |
| 56% | GARYCOLE | 8 | "Veep" actor who voices Principal Shepherd on 45-Across (2 wds.) |
| 56% | PHILLAMARR | 10 | "Mad TV" actor who voices Hermes Conrad on Hulu's revival of the animated series "Futurama" (2 wds.) |
| 56% | PAULREISER | 10 | "Mad About You" actor who voices Elliot Cooper on the Netflix animated series "Long Story Short": 2 wds. |
| 55% | ERICEDELSTEIN | 13 | Comedy actor who voices Grizzly on the Cartoon Network's "We Bare Bears" (2 wds.) |
| 55% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who voices Leela on "Futurama" (2 wds.) |
| 55% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who voices amnesiac chef Earl Harlan, a character on 15-/51-Across: 2 wds. |
| 55% | HANKAZARIA | 10 | "The Simpsons" voice actor who won an Emmy for his guest role as Ed Cochran on 43-Across: 2 wds. |
| 54% | DEMETRIMARTIN | 13 | Comedy actor who voices Ice Bear on "We Bare Bears" (2 wds.) |
| 54% | CHRISTOPHWALTZ | 14 | "No Time to Die" actor who voices Count Volpe in "Pinocchio" (2 wds.) |
| 54% | WILLARNETT | 10 | "Arrested Development" actor who voices the title character on 32-Across (2 wds.) |
| 54% | DANIELCRAIG | 11 | "Skyfall" actor who turned 50 on March 2, 2018 (2 wds.) |