| 100% | DAD | 3 | "American ___!" (Seth MacFarlane animated series) |
| 85% | GUY | 3 | "Family ___" (Seth MacFarlane animated series) |
| 81% | FAMILYGUY | 9 | Fox animated series created by Seth MacFarlane: 2 wds. |
| 80% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 71% | DAD | 3 | "American ___!" (Seth MacFarlane animated sitcom) |
| 71% | DAD | 3 | "American ___!" (Seth MacFarlane animated show) |
| 67% | DAD | 3 | "American ___!" (Seth MacFarlane series) |
| 64% | GUY | 3 | "Family ___," Seth MacFarlane's animated sitcom |
| 64% | AMERICANDAD | 11 | Animated Seth MacFarlane sitcom |
| 58% | GUY | 3 | "Family ___," American animated sitcom created by Seth MacFarlane |
| 58% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 58% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 42-Across (2 wds.) |
| 56% | BRAVO | 5 | "Johnny ___," American animated TV series created by Van Partible |
| 55% | PETER | 5 | ___ Griffin, popular television character voiced by Seth MacFarlane in the animated sitcom "Family Guy" |
| 50% | TED | 3 | Seth MacFarlane film |
| 50% | TED | 3 | Seth MacFarlane movie |
| 49% | DAD | 3 | "American ___!" (Fox animated series about the Smith family) |
| 49% | TIMON | 5 | "The Lion King's ___ & Pumbaa," American animated TV series created by Walt Disney Television Animation |
| 49% | DALE | 4 | "Chip 'n ___: Rescue Rangers," American animated comedy series created by Tad Stones and Alan Zaslove |
| 49% | DOO | 3 | "The Scooby-___ Show," American animated mystery comedy series created by Joe Ruby and Ken Spears |
| 49% | GEEKS | 5 | "Freaks and ___," American teen comedy-drama TV series created by Paul Feig starring Seth Rogen |
| 49% | AMERICAN | 8 | Seth MacFarlane created __ Dad |
| 49% | AMERICANDAD | 11 | Seth MacFarlane cartoon sitcom |
| 49% | GUY | 3 | Seth MacFarlane sitcom "Family ___" |
| 49% | DORA | 4 | Animated series "___ the Explorer" |
| 48% | GFORCE | 6 | 1980s American-Japanese animated series subtitled "Guardians of Space" |
| 48% | THECRITIC | 9 | Animated series starring Jon Lovitz |
| 48% | NED | 3 | "Nightmare ___," 1997 Disney animated series |
| 48% | KIM | 3 | "___ Possible" (2002-2007 animated series) |
| 48% | EDD | 3 | Animated series "Ed, ___ n Eddy" |