| 100% | DAD | 3 | "American ___!" (Seth MacFarlane series) |
| 89% | DAD | 3 | "American ___!" (Seth MacFarlane animated series) |
| 69% | GUY | 3 | "Family ___" (Seth MacFarlane animated series) |
| 66% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 66% | TED | 3 | Seth MacFarlane film |
| 66% | TED | 3 | Seth MacFarlane movie |
| 64% | GEEKS | 5 | "Freaks and ___," American teen comedy-drama TV series created by Paul Feig starring Seth Rogen |
| 64% | AMERICAN | 8 | Seth MacFarlane created __ Dad |
| 64% | AMERICANDAD | 11 | Seth MacFarlane cartoon sitcom |
| 64% | GUY | 3 | Seth MacFarlane sitcom "Family ___" |
| 62% | DAD | 3 | "American ___!" (Seth MacFarlane cartoon) |
| 61% | EMCEE | 5 | Seth MacFarlane, at the 2013 Oscars |
| 61% | DAD | 3 | "American ___!" (Seth MacFarlane animated sitcom) |
| 61% | DAD | 3 | "American ___!" (Seth MacFarlane animated show) |
| 61% | TED | 3 | 2012 Seth MacFarlane comedy |
| 61% | AMERICANDAD | 11 | Animated Seth MacFarlane sitcom |
| 60% | FAMILYGUY | 9 | Fox animated series created by Seth MacFarlane: 2 wds. |
| 60% | ATEAM | 5 | 1983 American action series |
| 59% | TED | 3 | Bear voiced by Seth MacFarlane |
| 59% | PIE | 3 | American ___ (Hit film series) |
| 58% | ACADEMYAWARDS | 13 | Seth MacFarlane hosted them in 2013: 2 wds. |
| 58% | EMCEE | 5 | Seth MacFarlane, at the 2013 Oscars, e.g. |
| 58% | FAMILYGUY | 9 | Seth MacFarlane's TV cartoon about the Griffins |
| 58% | TED | 3 | Seth MacFarlane film about a talking toy bear |
| 58% | TED | 3 | Seth MacFarlane movie about a talking stuffed animal |
| 58% | TED | 3 | Movie bear voiced by Seth MacFarlane |
| 58% | TED | 3 | Movie character voiced by Seth MacFarlane |
| 58% | TED | 3 | Stuffed bear voiced by Seth MacFarlane |
| 58% | TED | 3 | Foulmouthed bear voiced by Seth MacFarlane |
| 58% | TED | 3 | Two-time Seth MacFarlane title character |