| 100% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 72% | IANMCSHANE | 10 | The actor who plays Mr. Wednesday on the TV series "American Gods": 2 wds. |
| 70% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 68% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 67% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 64% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 64% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 63% | PEDROPASCAL | 11 | "Narcos" actor who plays the title character on "The Mandalorian" (2 wds.) |
| 63% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 63% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 63% | ANDREWLINCOLN | 13 | British actor who plays American Rick Grimes on AMC's "The Walking Dead": 2 wds. |
| 62% | CARLWEATHERS | 12 | "Predator" actor who plays Greef Karga on "The Mandalorian" (2 wds.) |
| 62% | JONBARINHOLTZ | 13 | "Superstore" actor who plays Wesley Payne, grandson of the former CEO, on "American Auto": 2 wds. |
| 62% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role on "Perry Mason" (2 wds.) |
| 62% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 62% | VICTAYBACK | 10 | Actor who played diner owner Mel on the sitcom "Alice": 2 wds. |
| 62% | ALEXKARRAS | 10 | Actor who played the adoptive father on "Webster": 2 wds. |
| 62% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 61% | STEVEBUSCEMI | 12 | "Boardwalk Empire" actor who played God on the first season of the TBS series "Miracle Workers" (2 wds.) |
| 61% | JERRYSTILLER | 12 | Jewish actor who played Italian American Frank Costanza on "Seinfeld": 2 wds. |
| 61% | PETERFALK | 9 | Jewish actor who played Italian American Lieutenant Columbo on "Columbo": 2 wds. |
| 61% | CHRISELLIOTT | 12 | "Groundhog Day" actor who plays the mayor on 19-Across: 2 wds. |
| 61% | JAREDLETO | 9 | "Suicide Squad" actor who plays Dr. Michael Morbius in the upcoming movie "Morbius": 2 wds. |
| 60% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 60% | RANDALLPARK | 11 | Actor who plays Louis, the dad on "Fresh Off the Boat": 2 wds. |
| 60% | JUDELAW | 7 | "Alfie" actor who played Dr. Watson in the movie "Sherlock Holmes": 2 wds. |
| 60% | DANNYBONADUCE | 13 | Actor who played the wisecracking middle child on "The Partridge Family": 2 wds. |
| 60% | SETHGREEN | 9 | Actor who played Daniel "Oz" Osbourne on "Buffy the Vampire Slayer": 2 wds. |
| 60% | FRANKIEMUNIZ | 12 | Actor who played child prodigy Malcolm on "Malcolm in the Middle": 2 wds. |
| 60% | MATTHEWRHYS | 11 | "The Americans" actor who plays Perry Mason on "Perry Mason" (2 wds.) |