| 100% | IFI | 3 | "And ___ were to refuse?": 2 wds. |
| 67% | IMEAN | 5 | "That is to say..": 2 wds. |
| 64% | WHYNOT | 6 | "I can't see a reason to refuse": 2 wds. |
| 63% | PATRICKROY | 10 | Former Montreal Canadiens goaltender who has 551 wins and is the only player in NHL history to win the Conn Smythe trophy thrice: 2 wds. |
| 62% | ASIF | 4 | "Live ___ you were to die tomorrow...": 2 wds. |
| 61% | BOJACKSON | 9 | American athlete who has also acted in minor roles, and is the only one to have been named "All-Star" in both football and baseball: 2 wds. |
| 61% | ISIT | 4 | "Whose fault ___?" ("Who is to blame?"): 2 wds. |
| 61% | CLAMUP | 6 | Refuse to speak: 2 wds. |
| 60% | LESS | 4 | What 1 is to 2 and 2 is to 3 |
| 60% | AFEW | 4 | "I have been to Seattle ___ times." (small number): 2 wds. |
| 60% | MARTINBRODEUR | 13 | Former New Jersey Devils' goaltender who has the highest number of wins with 691 wins and was elected to the Hockey Hall of Fame in 2018: 2 wds. |
| 60% | LIEAWAKE | 8 | Be unable to sleep: 2 wds. |
| 60% | OFUSE | 5 | Be ___ to (help): 2 wds. |
| 60% | OFUSE | 5 | Be ___ to (assist): 2 wds. |
| 59% | ONOR | 4 | "You are to submit your work ___ before this Friday": 2 wds. |
| 59% | IMEAN | 5 | "That is to say ... " (2 wds.) |
| 58% | INTROUBLE | 9 | About to be punished: 2 wds. |
| 58% | JORDANSPIETH | 12 | American golfer who won the 2017 Open Championship and was runner-up to 49-Across in the 2021 Open Championship (2 wds.) |
| 57% | SAYNO | 5 | Refuse to give permission: 2 wds. |
| 57% | SAYNO | 5 | Refuse to do something: 2 wds. |
| 57% | TOBED | 5 | "Early ___ and early to rise...": 2 wds. |
| 56% | SPORTCLIMBING | 13 | Wall-ascending event that was to make its debut at the 2020 Olympics: 2 wds. |
| 55% | IFA | 3 | "How much would the public benefit ___ new set of laws were to be passed?": 2 wds. |
| 55% | ASIT | 4 | ___ were (so to speak): 2 wds. |
| 55% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 55% | DANIELLESTEEL | 13 | American author who wrote "A Perfect Life" and is currently the bestselling author alive: 2 wds. |
| 55% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 55% | JOHNLENNON | 10 | English songwriter who co-founded the Beatles and is known for his song "Imagine": 2 wds. |
| 55% | ALOT | 4 | Leave ___ to be desired: 2 wds. |
| 55% | ENDUP | 5 | Turn out to be: 2 wds. |