| 100% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |
| 58% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 53% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 52% | ROSIEPEREZ | 10 | "White Men Can't Jump" actress who played Mookie's girlfriend Tina in "Do the Right Thing": 2 wds. |
| 51% | OLIVIACOOKE | 11 | "Ready Player One" actress who plays the pregnant girlfriend of a murdered man in 31-Across (2 wds.) |
| 50% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 49% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 49% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 49% | LESLIEJONES | 11 | Actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 49% | LAURADERN | 9 | Actress who plays Jennifer Fox in "The Tale" and has an Outstanding Lead Actress nomination for the 70th Emmys: 2 wds. |
| 48% | MIAWASIKOWSKA | 13 | Actress who played the daughter of 14- and 32-Across in "The Kids Are All Right": 2 wds. |
| 48% | PENELOPEANN | 11 | With 50-Across, "Carlito's Way" actress who plays the First Lady in 16-Across: 2 wds. |
| 48% | JANECURTIN | 10 | Actress who played Prymaat from the planet Remulak in 1993's "Coneheads": 2 wds. |
| 48% | LESLIEJONES | 11 | "Ghostbusters" actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 48% | JULIECHRISTIE | 13 | "Shampoo" actress who played Lara in the 1965 film version of 19-Across: 2 wds. |
| 48% | EMMAWATSON | 10 | "Harry Potter" actress who played Belle in 2017's "Beauty and the Beast": 2 wds. |
| 48% | BLAKELIVELY | 11 | Actress who plays the "It Girl" in "Gossip Girl": 2 wds. |
| 48% | BRIELARSON | 10 | Actress who plays the character of Carol Danvers, a former U.S. Air Force pilot in "Captain Marvel": 2 wds. |
| 48% | FAYEDUNAWAY | 11 | "Network" actress who played the fiancée of Paul Newman's architect character in "The Towering Inferno": 2 wds. |
| 48% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 47% | FRANCESFISHER | 13 | Actress who played Ruth DeWitt Bukater, Rose's widowed mother in the movie "Titanic": 2 wds. |
| 47% | BODEREK | 7 | Actress who played the "ten" in the 1979 film "10": 2 wds. |
| 47% | LORILOUGHLIN | 12 | Actress who plays Rebecca Donaldson-Katsopolis, Jesse's wife in the 1987 sitcom "Full House": 2 wds. |
| 47% | ANGELABASSETT | 13 | Actress who plays the queen mother of Wakanda in "Black Panther": 2 wds. |
| 47% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 47% | ZOESALDANA | 10 | Actress who played Gamora from the planet Zen-Whoberi in 2014's "Guardians of the Galaxy": 2 wds. |
| 47% | ANDREABARBER | 12 | Actress who played Kimmy Gibbler, D.J's best friend in the 1987 sitcom "Full House:" 2 wds. |
| 47% | KRYSTENRITTER | 13 | "Jessica Jones" actress who plays Lucy in the "Echoes" spin-off of 18-Across: 2 wds. |
| 46% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 46% | DEBBIEREYNOLDS | 14 | "The Singing Nun" actress who played the star's love interest in "Singin' in the Rain": 2 wds. |