| 100% | WILLARNETT | 10 | "Arrested Development" actor who voices the title character on 32-Across (2 wds.) |
| 76% | MICHAELCERA | 11 | "Arrested Development" actor who voices the title character in Netflix's "Scott Pilgrim Takes Off": 2 wds. |
| 66% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 65% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 63% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 62% | KALEYCUOCO | 10 | "The Flight Attendant" actress who voices the title character on HBO Max's animated "Harley Quinn": 2 wds. |
| 60% | WILLARNETT | 10 | Voice of the title character on 36-Across: 2 wds. |
| 60% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 59% | CHRISEVANS | 10 | "Knives Out" actor who voices the title character in "Lightyear" (2 wds.) |
| 59% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 59% | PEDROPASCAL | 11 | "Narcos" actor who plays the title character on "The Mandalorian" (2 wds.) |
| 59% | JAMESCORDEN | 11 | "The Late Late Show" host who voices the title character in 18-Across: 2 wds. |
| 57% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 57% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 56% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 55% | MIKEMYERS | 9 | "SNL" cast member (1989-1995) who voiced the title character in the "Shrek" movies: 2 wds. |
| 55% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 55% | SPENCERTRACY | 12 | Actor who played the lawyer based on Clarence Darrow in 32-Across: 2 wds. |
| 55% | WALTONGOGGINS | 13 | "Justified" actor who plays the main character Wade on 18-Across: 2 wds. |
| 54% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 54% | FREDRICMARCH | 12 | Actor who played the lawyer based on William Jennings Bryan in 32-Across: 2 wds. |
| 54% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 54% | WILWHEATON | 10 | "Star Trek: The Next Generation" actor who voices amnesiac chef Earl Harlan, a character on 15-/51-Across: 2 wds. |
| 54% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 54% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 53% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 53% | PATRICKSTEWART | 14 | "X-Men" actor who plays the title role on 50-Across (2 wds.) |
| 53% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 53% | PATTONOSWALT | 12 | "Ratatouille" actor who voices Matthew the Raven on "The Sandman": 2 wds. |
| 53% | PETERSELLERS | 12 | Actor who played Pres. Merkin Muffley, Group Capt. Lionel Mandrake, and the title character in 32-Across: 2 wds. |