| 100% | JONATHANFRAKES | 14 | "Beyond Belief: Fact or Fiction" host who plays Commander Riker on 50-Across (2 wds.) |
| 40% | ALANTUDYK | 9 | "Firefly" actor who plays Harry Vanderspeigle on 50-Across (2 wds.) |
| 39% | LISAWHELCHEL | 12 | Actress who played Blair on "The Facts of Life": 2 wds. |
| 39% | KIMFIELDS | 9 | Actress who played Tootie on "The Facts of Life": 2 wds. |
| 39% | MINDYCOHN | 9 | Actress who played Natalie on "The Facts of Life": 2 wds. |
| 38% | LAURENAMBROSE | 13 | "Six Feet Under" actress who plays adult Van on 50-Across (2 wds.) |
| 38% | CHARLOTTERAE | 12 | Actress who played Mrs. Garrett on "The Facts of Life": 2 wds. |
| 37% | PATRICKSTEWART | 14 | "X-Men" actor who plays the title role on 50-Across (2 wds.) |
| 37% | COREYREYNOLDS | 13 | "The Closer" actor who plays Sheriff Mike Thompson on 50-Across (2 wds.) |
| 37% | ZACHCHERRY | 10 | "The Great American Baking Show" host who plays memory-blocked worker Dylan on 17-Across: 2 wds. |
| 37% | ALFONSORIBEIRO | 14 | "Dancing With the Stars" host who played one of Ricky's friends on 19-Across: 2 wds. |
| 37% | SARATOMKO | 9 | "Once Upon a Time" actress who plays Asta Twelvetrees on 50-Across (2 wds.) |
| 36% | JANELYNCH | 9 | "Hollywood Game Night" host who played Sue Sylvester on "Glee": 2 wds. |
| 36% | DANIELLEFISHEL | 14 | Actress who plays Topanga Matthews on 33-Across: 2 wds. |
| 36% | BENFELDMAN | 10 | Actor who plays Jonah Simms on 17-Across: 2 wds. |
| 36% | HARRYANDERSON | 13 | Actor who played Judge Stone on 18-Across: 2 wds. |
| 36% | DONADAMS | 8 | Actor who played Agent 86 on 16-Across: 2 wds. |
| 36% | BARBARAFELDON | 13 | Actress who played Agent 99 on 16-Across: 2 wds. |
| 36% | JAMESBROLIN | 11 | Actor who played a physician on 28-Across: 2 wds. |
| 36% | JOELMCHALE | 10 | "Card Sharks" (2019) host who played disbarred lawyer Jeff Winger on "Community" (2 wds.) |
| 36% | CHRISTINARICCI | 14 | "Z: The Beginning of Everything" actress who plays adult Misty on 50-Across (2 wds.) |
| 36% | ISABELSANFORD | 13 | Actress who played Louise on 15-Across: 2 wds. |
| 36% | CARROLLOCONNOR | 14 | Actor who played Archie on 16-Across: 2 wds. |
| 35% | JOHNOHURLEY | 11 | Former "Family Feud" host who plays J. Peterman on "Seinfeld" (2 wds.) |
| 35% | JAMESMARSDEN | 12 | "X-Men" actor who plays the host Teddy Flood on HBO's "Westworld" (2 wds.) |
| 35% | SARAHCHALKE | 11 | "Scrubs" actress who plays Kate Mularkey on 19-Across: 2 wds. |
| 35% | KATHERINEHEIGL | 14 | "Suits" actress who plays Tully Hart on 19-Across: 2 wds. |
| 35% | DAVEEDDIGGS | 11 | "Hamilton" actor who plays Andre Layton on 13-Across: 2 wds. |
| 35% | LAURENGRAHAM | 12 | "Parenthood" actress who played mother Lorelai on 14-Across: 2 wds. |
| 35% | ABIGAILSPENCER | 14 | "Timeless" actress who plays Julia on 15-Across: 2 wds. |