| 100% | EDBEGLEYJR | 10 | "Bless This Mess" actor who played Dr. Victor Ehrlich on "St. Elsewhere": 3 wds., abbr. |
| 52% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 47% | ALANHALEJR | 10 | Actor who played the Skipper on "Gilligan's Island": 3 wds., abbr. |
| 43% | DAVID | 5 | With 29-Across, "Treme" actor who played Dr. Jack Morrison on "St. Elsewhere" |
| 42% | STERLINGKBROWN | 14 | "Army Wives" actor who plays Randall Pearson on "This Is Us": 3 wds. |
| 42% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 42% | RICHARDEGRANT | 13 | "Can You Ever Forgive Me?" actor who plays Octavio on "Dispatches from Elsewhere" (3 wds.) |
| 41% | JOHNCREILLY | 11 | "Chicago" actor who plays Dr. Watson in "Holmes & Watson": 3 wds. |
| 41% | CRAIGTNELSON | 12 | Actor who played Hayden Fox on "Coach": 3 wds. |
| 41% | JONNYLEEMILLER | 14 | Actor who played Sherlock Holmes on "Elementary": 3 wds. |
| 41% | MAXBAERJR | 9 | Actor who played Jethro on "The Beverly Hillbillies": 3 wds. |
| 41% | HARRISONFORD | 12 | "1923" actor who plays Dr. Paul Rhoades on "Shrinking" (2 wds.) |
| 41% | MICHAELJFOX | 11 | Actor who played Alex P. Keaton on "Family Ties": 3 wds. |
| 40% | DICKVANPATTEN | 13 | Actor who played widowed father Tom Bradford on "Eight Is Enough": 3 wds. |
| 40% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 40% | TIMOTHYSIMONS | 13 | "Veep" actor who plays Sasha on "Nobody Wants This": 2 wds. |
| 39% | JESSELMARTIN | 12 | Actor who played Detective Ed Green for nine seasons on "Law & Order": 3 wds. |
| 39% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 39% | WILLIAMHMACY | 12 | "Fargo" actor who plays 17-Across's father on "Shameless": 3 wds. |
| 39% | JERRYVANDYKE | 12 | Actor who played Luther Van Dam on "Coach": 3 wds. |
| 39% | CRAIGTNELSON | 12 | Actor who played Coach Hayden Fox on "Coach": 3 wds. |
| 39% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 39% | ROBERTDOWNEYJR | 14 | "The Avengers" actor who played the title role in "Chaplin": 3 wds., abbr. |
| 39% | CRAIGTNELSON | 12 | "Coach" actor who plays baseball coach Dale Ballard on "Young Sheldon": 3 wds. |
| 39% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 38% | RONLEIBMAN | 10 | "Norma Rae" actor who played Rachel's father, Dr. Leonard Green, on "Friends": 2 wds. |
| 38% | JAMESBROLIN | 11 | "Life in Pieces" actor who played Dr. Steve Kiley on 30-Across (2 wds.) |
| 38% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 38% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 38% | BRYSHEREYGRAY | 13 | Actor who plays Hakeem Lyon on "Empire" (3 wds.) |