| 100% | LISAANNWALTER | 13 | "Bruce Almighty" actress who plays a teacher and ally of 15-Across: 3 wds. |
| 62% | CHRISPERFETTI | 13 | "Looking" actor who plays a history teacher and ally of 15-Across: 2 wds. |
| 46% | FRANDRESCHER | 12 | "Hotel Transylvania" voice actress who plays a beauty school teacher in "The Beautician and the Beast" (2 wds.) |
| 44% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 44% | ELIZABETHOLSEN | 14 | Actress who plays a powerful witch in Marvel's "Avengers" films and on 44-Across (2 wds.) |
| 44% | ANNEBANCROFT | 12 | Actress who won a Tony and an Oscar for playing Helen Keller's teacher in "The Miracle Worker": 2 wds. |
| 44% | ZACEFRON | 8 | Actor who plays a protégé of 15-Across in "The Greatest Showman": 2 wds. |
| 44% | JESSICATANDY | 12 | "Driving Miss Daisy" actress who played 15-Across in the original 1940s stage production of "A Streetcar Named Desire": 2 wds. |
| 43% | ANTONIATHOMAS | 13 | Actress who plays Shaun's friend and fellow resident Claire on 15-Across: 2 wds. |
| 43% | ANYATAYLORJOY | 13 | "Split" and "Glass" actress who plays 43-Across in a 2020 film (3 wds.) |
| 42% | MARGOTROBBIE | 12 | Actress who played 14-Across, 26-Across, and Queen Elizabeth I in "Mary Queen of Scots" (2 wds.) |
| 42% | MIAWASIKOWSKA | 13 | Actress who played the daughter of 14- and 32-Across in "The Kids Are All Right": 2 wds. |
| 42% | HOPEDAVIS | 9 | "Wayward Pines" actress who plays the wife of a mob boss on 54-Across (2 wds.) |
| 42% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 42% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 42% | WHOOPIGOLDBERG | 14 | "Sister Act" actress who played God in the films "A Little Bit of Heaven" and "It's a Very Merry Muppet Christmas Movie" (2 wds.) |
| 42% | DANADELANY | 10 | "China Beach" actress who played a medical examiner on "Body of Proof": 2 wds. |
| 42% | JADEPETTYJOHN | 13 | "School of Rock" and "Little Fires Everywhere" actress who plays a kidnapped teen on 1-Across/65-Across (2 wds.) |
| 41% | OLIVIACOOKE | 11 | "Ready Player One" actress who plays the pregnant girlfriend of a murdered man in 31-Across (2 wds.) |
| 41% | DIANEKEATON | 11 | Actress who plays a mother in "Father of the Bride" (2 wds.) |
| 41% | FRANFINE | 8 | Title character of 15-Across, whose first name is shared by actress Drescher who plays her: 2 wds. |
| 41% | DIANELANE | 9 | "Unfaithful" actress who plays Penny Chenery, the owner of 33-Across, in a 2010 film (2 wds.) |
| 41% | RACHELMCADAMS | 13 | "Spotlight" actress who plays a surgeon in "Doctor Strange in the Multiverse of Madness" (2 wds.) |
| 41% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 40% | OLIVIACOLMAN | 12 | "Broadchurch" actress who plays Queen Elizabeth in season 3 of "The Crown" (2 wds.) |
| 40% | JAMIELEECURTIS | 14 | "Halloween" actress who plays a principal in "Spare Parts": 3 wds. |
| 40% | MARLEEMATLIN | 12 | "CODA" actress who played a deaf employee at the school in "Children of a Lesser God": 2 wds. |
| 40% | WHITNEYHOUSTON | 14 | Singer and actress who played Rachel Marron in 18a and whose cover of "I Will Always Love You" became a best-selling single: 2 wds. |
| 40% | MARISATOMEI | 11 | "My Cousin Vinny" actress who plays a teacher in "Spare Parts": 2 wds. |
| 39% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |