| 100% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 63% | MARLEEMATLIN | 12 | "CODA" actress who played a deaf employee at the school in "Children of a Lesser God": 2 wds. |
| 61% | WHOOPIGOLDBERG | 14 | "Sister Act" actress who played God in the films "A Little Bit of Heaven" and "It's a Very Merry Muppet Christmas Movie" (2 wds.) |
| 58% | MARISATOMEI | 11 | "My Cousin Vinny" actress who plays 30-Across's mother in "The King of Staten Island": 2 wds. |
| 56% | LESLIEJONES | 11 | Actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 54% | LESLIEJONES | 11 | "Ghostbusters" actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 54% | EVALONGORIA | 11 | "Overboard" actress who plays Dora's mother in "Dora and the Lost City of Gold": 2 wds. |
| 54% | BRIELARSON | 10 | Actress who plays the character of Carol Danvers, a former U.S. Air Force pilot in "Captain Marvel": 2 wds. |
| 53% | DIANEKEATON | 11 | Actress who plays a mother in "Father of the Bride" (2 wds.) |
| 53% | ANGELABASSETT | 13 | Actress who plays the queen mother of Wakanda in "Black Panther": 2 wds. |
| 53% | SONJASOHN | 9 | "The Wire" actress who plays Nancy, the title boxer's mother, in a 2023 biopic about 40-Across (2 wds.) |
| 53% | AUBREYPLAZA | 11 | Actress who plays a profane 14th-century nun in "The Little Hours": 2 wds. |
| 53% | MARLEEMATLIN | 12 | "Children of a Lesser God" star who is the youngest winner of the Academy Award for Best Actress (2 wds.) |
| 53% | SANDRABULLOCK | 13 | "Gravity" actress who plays a romance novelist in 27-Across (2 wds.) |
| 52% | SALLYHAWKINS | 12 | "The Shape of Water" actress who plays Willy Wonka's mother in "Wonka": 2 wds. |
| 52% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 52% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |
| 51% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 51% | MERYLSTREEP | 11 | Actress who plays a mother in "Mamma Mia!" (2 wds.) |
| 51% | DIANELANE | 9 | "Unfaithful" actress who plays Penny Chenery, the owner of 33-Across, in a 2010 film (2 wds.) |
| 51% | SANDRABULLOCK | 13 | Actress who plays a mother in "The Blind Side" (2 wds.) |
| 50% | SUTTONFOSTER | 12 | "Younger" actress who played Princess Winnifred in the 2024 Broadway revival of "Once Upon a Mattress": 2 wds. |
| 50% | MAUDEAPATOW | 11 | "This Is 40" actress who plays 30-Across's sister in "The King of Staten Island": 2 wds. |
| 50% | OLIVIACOOKE | 11 | "Ready Player One" actress who plays the pregnant girlfriend of a murdered man in 31-Across (2 wds.) |
| 50% | WILLIAMHURT | 11 | "Broadcast News" actor (1950-2022) who played a speech teacher at a deaf school in "Children of a Lesser God": 2 wds. |
| 50% | AMYPOEHLER | 10 | Actress who played the role of Leslie Knope in "Parks and Recreation", a role she is best-known for: 2 wds. |
| 50% | MARLEEMATLIN | 12 | Performer who won an Academy Award for Best Actress for playing Sarah Norman in her film debut, "Children of a Lesser God" (2 wds.) |
| 50% | HALLEBAILEY | 11 | Actress who plays a mermaid named Ariel in "The Little Mermaid" (2 wds.) |
| 49% | GRACEKELLY | 10 | Actress who played a socialite in Hitchcock's "Dial M for Murder": 2 wds. |
| 49% | JULIANNEMOORE | 13 | Actress who plays an activist aiding a pregnant woman in a dystopian retelling of the nativity story in "Children of Men" (2 wds.) |