| 100% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 73% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title GBI special agent on 50-Across (2 wds.) |
| 72% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 71% | PATRICKSTEWART | 14 | "X-Men" actor who plays the title role on 50-Across (2 wds.) |
| 69% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 69% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 67% | ALANRITCHSON | 12 | "Titans" actor who plays the title role on the Amazon series "Reacher" (2 wds.) |
| 67% | CRAIGTNELSON | 12 | "Parenthood" actor who plays the title role on 60-Across (3 wds.) |
| 67% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 66% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role on "Perry Mason" (2 wds.) |
| 63% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 63% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 63% | BOBODENKIRK | 11 | "Breaking Bad" actor who plays the lead role on 33-Across: 2 wds. |
| 62% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 61% | MICHAELKEATON | 13 | "Mr. Mom" actor who played the title role in 40-Across (2 wds.) |
| 61% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 60% | LIEVSCHREIBER | 13 | "Spotlight" actor who has been nominated for three Emmys for playing the title role on 43-Across: 2 wds. |
| 59% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 59% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 59% | BILLHADER | 9 | Former "Saturday Night Live" cast member who plays the title role on 4-Across (2 wds.) |
| 59% | DEREKJACOBI | 11 | "The King's Speech" actor who plays the title role in the film "Cyrano de Bergerac" (2 wds.) |
| 59% | ELBA | 4 | Actor who played the title role on “Luther” |
| 58% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 58% | LIAMNEESON | 10 | "Schindler's List" actor who plays the title role in "Marlowe" (2 wds.) |
| 57% | TARONEGERTON | 12 | "Rocketman" actor who plays the title role in the 2018 film "Robin Hood" (2 wds.) |
| 57% | RUSSELLCROWE | 12 | "Gladiator" actor who plays the title role in the 2010 film "Robin Hood" (2 wds.) |
| 57% | DWAYNEJOHNSON | 13 | "Hobbs & Shaw" actor who plays the title role in "Black Adam" (2 wds.) |
| 56% | RUSSELLCROWE | 12 | "Gladiator" actor who played the title boy's father in "Boy Erased": 2 wds. |
| 55% | NABORS | 6 | Actor Jim who played the title role on "Gomer Pyle, U.S.M.C." |
| 55% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |