| 100% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 78% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 76% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 76% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 75% | BROOKESHIELDS | 13 | "The Blue Lagoon" actress who played the title character on 46-Across (2 wds.) |
| 73% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 72% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 71% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 71% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character, 46-Across, on a Netflix miniseries (2 wds.) |
| 68% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 67% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 67% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 66% | TOMHIDDLESTON | 13 | "Kong: Skull Island" star who plays the title character on "Loki": 2 wds. |
| 66% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 66% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |
| 65% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 63% | EMILYBLUNT | 10 | "The Girl on the Train" star who plays the title character in "Mary Poppins Returns": 2 wds. |
| 63% | REBECCABREEDS | 13 | "Pretty Little Liars" actress who plays the title FBI agent on 34-Across (2 wds.) |
| 62% | PEDROPASCAL | 11 | "Narcos" actor who plays the title character on "The Mandalorian" (2 wds.) |
| 62% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 62% | ALLISONJANNEY | 13 | Actress who plays Bonnie, the title mom on "Mom": 2 wds. |
| 61% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 60% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 59% | KALEYCUOCO | 10 | "The Flight Attendant" actress who voices the title character on HBO Max's animated "Harley Quinn": 2 wds. |
| 58% | GRACEDOVE | 9 | The Revenant" actress who plays Roz on 44-Across (2 wds.) |
| 58% | CYNTHIANIXON | 12 | "Sex and the City" actress who plays socialite Ada Brook on 44-Across (2 wds.) |
| 57% | EDIE | 4 | Actress Falco who played the title character on "Nurse Jackie" |
| 57% | TAISSAFARMIGA | 13 | "American Horror Story" actress who plays the naive Gladys Russell on 17-Across: 2 wds. |
| 57% | JULIAGARNER | 11 | "Ozark" actress who plays the title con artist in 30-Across (2 wds.) |
| 57% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |