| 100% | MOON | 4 | "Destination" in a 1950 sci-fi film |
| 67% | MMI | 3 | Year in a Roman sci-fi film? |
| 63% | KPAX | 4 | Title planet in a 2001 sci-fi film |
| 61% | ALIEN | 5 | Figure in many a sci-fi film |
| 60% | HANSOLO | 7 | Killer of Greedo in a sci-fi film |
| 60% | APES | 4 | Heston's jailors, in a sci-fi film |
| 59% | DARYL | 5 | 1985 sci-fi film featuring Barret Oliver in the title role as a cyborg |
| 58% | ROLLERBALL | 10 | Titular sport in a 1975 dystopian sci-fi film |
| 58% | TRON | 4 | 1982 sci-fi film set in a computer |
| 56% | IROBOT | 6 | 2004 sci-fi film based on a 1950 book |
| 56% | INCEPTION | 9 | A 2010 Sci-Fi film by Christopher Nolan in which Tom Hardy plays a fence who can impersonate others expertly |
| 55% | ASPACEODYSSEY | 13 | Subtitle of a classic sci-fi film that premiered in April 1968 (3 wds.) |
| 55% | COVENANT | 8 | Sci-fi horror film directed by Ridley Scott, "Alien: ___," which is a sequel to "Prometheus," and released in 2017 |
| 54% | THEMATRIX | 9 | A 1999 Sci-Fi film in which Keanu Reeves - whose birthday it is today - portrays the main character, named "Neo": 2 wds. |
| 54% | SUNSETBOULEVARD | 15 | Title locale in a 1950 Billy Wilder film noir |
| 52% | TOEARTH | 7 | How David Bowie's character fell, in a 1976 sci-fi film |
| 52% | HAMM | 4 | Actor Jon who plays a hologram in the sci-fi film "Marjorie Prime" |
| 51% | APES | 4 | Captors in a sci-fi classic |
| 50% | TEK | 3 | Drug in a sci-fi Shatner novel |
| 50% | UFO | 3 | Ship in a sci-fi story: Abbr. |
| 50% | TEK | 3 | Drug in a sci-fi novel series |
| 50% | HUMANRACE | 9 | "Our" side in a sci-fi battle |
| 50% | APES | 4 | Simians in a popular sci-fi franchise |
| 50% | GALACTICA | 9 | Titular ship in a sci-fi series |
| 50% | POINTB | 6 | Destination in a simple itinerary |
| 50% | ALIEN | 5 | Sci-fi film with a hatching egg on its poster |
| 49% | TRON | 4 | 1982 sci-fi film with a 2010 sequel |
| 49% | JURASSIC | 8 | __ Park, sci-fi film about a dinosaur park |
| 49% | GORDON | 6 | Flash __, sci-fi film with a Queen soundtrack |
| 49% | TRYON | 5 | Tom —, US actor who starred in 1958 sci-fi film I Married a Monster from Outer Space |