| 100% | WHICHDOCTOR | 11 | "Did you mean Doom or Dolittle?"? |
| 54% | WHAT | 4 | "__ do you mean?" |
| 54% | WHAT | 4 | "___ do you mean?" |
| 52% | HUH | 3 | "___? What do you mean?" |
| 52% | HUH | 3 | "What do you mean?" |
| 51% | WHO | 3 | "Which person do you mean?" |
| 50% | HUH | 3 | "___? What do you mean?" (confused exclamation) |
| 50% | WHAT | 4 | "Just ___ do you mean by that?" |
| 50% | DEFINENORMAL | 12 | "What exactly do you mean by 'typical'?" |
| 48% | INTENT | 6 | What you mean to do |
| 47% | NEEDIGOON | 9 | “. . . do you want more examples, or what?” |
| 47% | SEE | 3 | "Now do you ___ what I meant?" |
| 45% | WAYS | 4 | Means or methods of doing something |
| 45% | INCONSOLABLY | 12 | "What do you mean there are no PlayStations left in stock?" asked Tom ___ |
| 44% | BYTHEWAY | 8 | You mean this when adding BTW to a mail or text |
| 44% | ISTHATATHING | 12 | "What do you think ... real or not?" |
| 44% | EITHER | 6 | "___ you do it, or I will!" |
| 44% | BIEBER | 6 | Singer Justin whose first No. 1 hit was 2015's "What Do You Mean?" |
| 42% | SEE | 3 | “Did I tell you or did I tell you?” |
| 42% | FERMENT | 7 | You must do it to make miso, sauerkraut, or kimchi |
| 42% | TOSS | 4 | You might do it to a coin or a salad |
| 41% | RUE | 3 | Feel sorrow, remorse or regret something you did |
| 41% | DEVOTION | 8 | Adoration, meaning you'd do anything for someone |
| 41% | HANG | 4 | You can do this tough or you can do it tight |
| 41% | PET | 3 | Dog or cat, or what you do to it |
| 41% | LUMPIT | 6 | Like it or __, means you'll need to endure |
| 41% | PUMP | 4 | What you might do with gas or a fist |
| 41% | TRICK | 5 | On Halloween, you either do this or get treats |
| 41% | PET | 3 | Furry friend, or what you might do to one |
| 40% | SIMON | 5 | Do what he says or you lose |