| 100% | BRUCEWILLIS | 11 | "Die Hard" actor who plays a man with superhuman strength in "Unbreakable" and 62-Across (2 wds.) |
| 66% | SAMUELLJACKSON | 14 | "The Avengers" actor who plays a man with extremely fragile bones in "Unbreakable" and 62-Across (3 wds.) |
| 62% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" actor who plays a man with multiple personalities in 1-Across and 62-Across (2 wds.) |
| 53% | ROBERTDUVALL | 12 | Oscar-winning actor who played a man in love with a tiny doll on "The Twilight Zone": 2 wds. |
| 50% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 50% | ALANRICKMAN | 11 | "Die Hard" actor who played Colonel Brandon in "Sense and Sensibility": 2 wds. |
| 48% | PAULBETTANY | 11 | Actor who plays a powerful android in Marvel's "Avengers" films and on 44-Across (2 wds.) |
| 48% | FREDASTAIRE | 11 | "Top Hat" actor who played a con man in "The Towering Inferno": 2 wds. |
| 47% | LESLIENIELSEN | 13 | "Airplane!" actor who played a vampire in the comedy "Dracula: Dead and Loving It": 2 wds. |
| 46% | JONATHANPRYCE | 13 | "Pirates of the Caribbean" actor who played a Bond villain in 1997's "Tomorrow Never Dies": 2 wds. |
| 46% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 46% | JANESEYMOUR | 11 | "Dr. Quinn, Medicine Woman" star who played a Bond girl in "Live and Let Die": 2 wds. |
| 46% | JUDDNELSON | 10 | Actor who played a high school delinquent in "The Breakfast Club" and a yuppie politician in "St. Elmo's Fire": 2 wds. |
| 46% | EMILIOESTEVEZ | 13 | Actor who played a high school jock in "The Breakfast Club" and a law student in "St. Elmo's Fire": 2 wds. |
| 46% | MICHAELKEATON | 13 | "Spotlight" actor who has played a Marvel supervillian in "Spider-Man: Homecoming" and a DC superhero in "Batman": 2 wds. |
| 45% | ZACEFRON | 8 | Actor who plays a protégé of 15-Across in "The Greatest Showman": 2 wds. |
| 45% | CHRISEVANS | 10 | "Avengers: Endgame" actor who plays a cult leader in 15-Across: 2 wds. |
| 45% | ERICBANA | 8 | Actor who played 32-Across in a 2003 film: 2 wds. |
| 45% | EDWARDNORTON | 12 | Actor who played 32-Across in a 2008 film: 2 wds. |
| 45% | PETERSTORMARE | 13 | Actor who plays John Abruzzi and is a prominent figure at Fox River State Penitentiary in "Prison Break": 2 wds. |
| 45% | VINCEVAUGHN | 11 | "Dodgeball" and "The Internship" actor who plays a killer who changes bodies with Millie in "Freaky" (2 wds.) |
| 45% | COLINFIRTH | 10 | "The King's Speech" actor who played painter Johannes Vermeer in "Girl With a Pearl Earring": 2 wds. |
| 45% | BRUCEWILLIS | 11 | "A Good Day to Die Hard" actor who stars in 49-Across: 2 wds. |
| 45% | CHRISPERFETTI | 13 | "Looking" actor who plays a history teacher and ally of 15-Across: 2 wds. |
| 45% | GENEWILDER | 10 | Actor who played 31-/34-Across in a 1971 film: 2 wds. |
| 45% | JOHNNYDEPP | 10 | Actor who played 31-/34-Across in a 2005 film: 2 wds. |
| 44% | DAVIDHARBOUR | 12 | "Stranger Things" actor who plays a veteran race car driver and trainer in "Gran Turismo" (2 wds.) |
| 44% | EWANMCGREGOR | 12 | Actor who played 29-/32-Across in the 1990s and 2000s: 2 wds. |
| 44% | ALECGUINNESS | 12 | Actor who played 29-/32-Across in the 1970s and 1980s: 2 wds. |
| 44% | BRUCEWILLIS | 11 | "Die Hard" actor who plays Frank Minna in "Motherless Brooklyn": 2 wds. |