| 100% | ARE | 3 | "Earth Girls ___ Easy" (1988 comedy) |
| 46% | MOONOVERPARADOR | 15 | 1988 comedy starring Richard Dreyfuss and Raul Julia |
| 46% | BIG | 3 | 1988 comedy starring Tom Hanks and Elizabeth Perkins |
| 46% | MOONOVERPARADOR | 15 | 1988 Dreyfuss-Julia comedy |
| 46% | BIG | 3 | 1988 Tom Hanks comedy |
| 46% | RENTACOP | 8 | 1988 security guard comedy |
| 44% | COCKTAIL | 8 | 1988 comedy-drama film starring Tom Cruise and Bryan Brown |
| 44% | HAIRSPRAY | 9 | 1988 comedy-drama film starring Sonny Bono and Ruth Brown |
| 44% | HEATHERS | 8 | 1988 comedy-drama film starring Winona Ryder and Christian Slater |
| 44% | BEACHES | 7 | 1988 comedy-drama film starring Bette Midler and Barbara Hershey |
| 43% | LES | 3 | "___ Girls," 1957 musical comedy |
| 42% | GILMORE | 7 | Popular comedy TV series "___ Girls" |
| 41% | TEENAGE | 7 | Girl Talk is a 1988 game for __ girls |
| 41% | NAKEDGUN | 8 | "The" 1988 Leslie Nielsen comedy, with |
| 41% | FRIDAY | 6 | His Girl __, Hawks' wisecracking newspaper comedy |
| 40% | BIG | 3 | 1988 film comedy starring Tom Hanks and Elizabeth Perkins |
| 40% | AFISHCALLEDWA | 13 | 1988 crime comedy rated 93% positive on Rotten Tomatoes |
| 40% | SCROOGED | 8 | 1988 film comedy starring Bill Murray and Karen Allen |
| 40% | GOLDEN | 6 | The __ Girls; comedy about elderly house-sharers |
| 40% | WANDA | 5 | Title fish in a 1988 heist comedy |
| 40% | AMELIE | 6 | Title girl in a 2001 French comedy |
| 39% | WORKING | 7 | __ Girl, 1988 film starring Melanie Griffith |
| 39% | RAINMAN | 7 | 1988 comedy-drama starring Dustin Hoffman and Tom Cruise; 1989 Best Picture Oscar winner |
| 39% | RAINMAN | 7 | 1988 comedy-drama that features The Beatles' "I Saw Her Standing There": 2 wds. |
| 39% | BEETLEJUICE | 11 | 1988 film comedy starring Michael Keaton in the title role |
| 39% | MIDNIGHTRUN | 11 | 1988 film comedy starring Robert De Niro and Charles Grodin |
| 38% | MEAN | 4 | "___ Girls" (teen comedy movie) |