| 100% | ERMA | 4 | "Family: The Ties That Bind ... and Gag!" humorist Bombeck |
| 50% | CORSET | 6 | The ties that bind? |
| 47% | BLEST | 5 | "___ Be the Tie That Binds" (Christian hymn) |
| 39% | FIGWORT | 7 | Family of flowering plants that includes the Ningpo — and Mimbres — |
| 39% | FIGWORT | 7 | Family of flowering plants that includes the Ningpo - and Mimbres - |
| 38% | ARUM | 4 | Family that includes the jack-in-the-pulpit and skunk cabbage |
| 38% | WIZ | 3 | The —, 1978 family film that starred Diana Ross and Michael Jackson |
| 38% | ROMANCE | 7 | Family that includes the languages spoken in 13- and 15-Across |
| 38% | SOAP | 4 | US sitcom that featured the Tate and Campbell families |
| 38% | TRUSSES | 7 | Ties that bind |
| 38% | STRAP | 5 | Tie that binds |
| 37% | SOAP | 4 | US television sitcom that featured the Tate and Campbell families |
| 37% | DYNASTY | 7 | US television drama series that featured the Colby and Carrington families |
| 37% | NIGHTSHADE | 10 | Family that includes the potato, eggplant and tobacco |
| 37% | OBI | 3 | Tie that binds, in Japan? |
| 36% | HELENIUM | 8 | Genus of plants of the daisy family that includes Rosilla and Yellowdicks |
| 36% | UNSER | 5 | Surname of the auto racing family that includes Al, Al Junior, and Bobby |
| 35% | BIND | 4 | The ties that ___ (unifying factors that link people) |
| 35% | GEESE | 5 | Birds that belong to the same family as ducks, and migrate in the fall season |
| 35% | ERMAS | 5 | Humorist Bombeck and others |
| 34% | MOVIE | 5 | "Home ___," 2008 found footage film that follows the Poe family and the secret of their twins |
| 34% | ASTER | 5 | Daisy-like flower that is a member of the sunflower family and blooms late in fall |
| 34% | BLACK | 5 | Surname for a wizarding family in the "Harry Potter" series that has members like Sirius and Regulus |
| 34% | MALFOY | 6 | Surname for a wizarding family in the "Harry Potter" series that has members like Draco and Lucius |
| 33% | CYTOSINE | 8 | The nucleotide that binds with guanine |
| 33% | VACATION | 8 | "Jersey Shore Family ___," reality TV series that was a revival and sequel of the original "Jersey Shore" series |
| 32% | ECTO | 4 | Hi-C ___ Cooler, beverage that had a tie-in with the Ghostbusters brand and was famous in the 80s |
| 32% | ERMA | 4 | Humorist Bombeck who wrote "Motherhood: The Second Oldest Profession" |
| 32% | ESTE | 4 | Noble family of Italy that governed Modena and Reggio from the 13th to the 18th century |
| 32% | ESTE | 4 | Noble family of Italy that governed Modena and Reggio from the 13th- to the 18th-century |