| 100% | SETHMACFARLANE | 14 | "Family Guy" creator who wore a motion-capture suit to portray the title character in "Ted": 2 wds. |
| 67% | JOSHBROLIN | 10 | "Sicario" actor who wore a motion-capture suit to portray Thanos in the "Avengers" movies: 2 wds. |
| 62% | ZOESALDANA | 10 | "Guardians of the Galaxy" actress who wore a motion-capture suit to portray Neytiri in "Avatar": 2 wds. |
| 43% | JIMMYKIMMEL | 11 | ABC late-night host who wears a suit and tie in the "Happy" video: 2 wds. |
| 43% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 42% | RENEEZELLWEGER | 14 | Actress who returns to play the title character in "Bridget Jones: Mad About the Boy": 2 wds. |
| 42% | BUTCHCASSIDY | 12 | Title character in a classic western film who asks, "Who are those guys?" (2 wds.) |
| 40% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 39% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 39% | KELLYOSBOURNE | 13 | Reality TV star who wears a purple wig in the "Happy" video: 2 wds. |
| 38% | MISSDAISY | 9 | Title character whom 15-Across chauffeured around in a 1989 film: 2 wds. |
| 38% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 38% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 38% | PRINCESSPEACH | 13 | Royal character in the Super Mario games who wears a pink dress with a gold crown: 2 wds. |
| 37% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 37% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 37% | VITOCORLEONE | 12 | Character who has the title role in 15-Across: 2 wds. |
| 37% | ALECBALDWIN | 11 | Actor who made a cameo in "Glengarry Glen Ross" by playing the role of Blake, the guy who is sent to motivate the sales team: 2 wds. |
| 36% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 36% | PETERGRIFFIN | 12 | The main character and father of the family in the American sitcom, "Family Guy": 2 wds. |
| 36% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 35% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 35% | SETH | 4 | MacFarlane who voices the title character in the upcoming "Ted 2" |
| 35% | JAREDLETO | 9 | Actor who wore contacts he couldn't see through to play a blind villain in "Blade Runner 2049": 2 wds. |
| 35% | SETHMACFARLANE | 14 | Creator of the American animated sitcom "Family Guy" who also voices other characters of the show: 2 wds. |
| 35% | BLACKLIGHTNING | 14 | Superhero dad who was the title character on a show on a 2018-2021 CW show: 2 wds. |
| 35% | MICHAELCERA | 11 | "Arrested Development" actor who voices the title character in Netflix's "Scott Pilgrim Takes Off": 2 wds. |
| 34% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 34% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 34% | BLAKELIVELY | 11 | Actress who wore contact lenses she couldn't see through to play a blind woman in "All I See Is You": 2 wds. |