| 100% | STEVEMARTIN | 11 | "Father of the Bride" actor who won the Mark Twain Prize for American Humor in 2005: 2 wds. |
| 80% | EDDIEMURPHY | 11 | "The Nutty Professor" actor and "SNL" star who won the Mark Twain Prize for American Humor in 2015: 2 wds. |
| 80% | WILLFERRELL | 11 | "Elf" actor and "Saturday Night Live" star who won the Mark Twain Prize for American Humor in 2011: 2 wds. |
| 76% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 65% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 64% | LENO | 4 | Jay who won the Mark Twain Prize for American Humor in 2014 |
| 64% | LENO | 4 | Jay ___, TV host who won the Mark Twain Prize for American Humor in 2014 |
| 60% | WILLFERRELL | 11 | "Elf" actor who roasted 2025 Mark Twain Prize for American Humor honoree Conan O'Brien: 2 wds. |
| 60% | ADAMSANDLER | 11 | "Grown Ups" actor who won the Mark Twain Prize in 2023: 2 wds. |
| 59% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 58% | FEY | 3 | Tina who won the Mark Twain Prize for American Humor |
| 56% | LORNEMICHAELS | 13 | "Saturday Night Live" creator who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 56% | EDDIEMURPHY | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 56% | WILLFERRELL | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 55% | CONAN | 5 | O’Brien who was awarded the Mark Twain Prize for American Humor, in 2025 |
| 53% | ARTHURASHKIN | 12 | American scientist who won one half of the 2018 Nobel Prize in Physics for his work on optical tweezers: 2 wds. |
| 51% | FEY | 3 | Tina who won a Mark Twain Prize for American Humor |
| 51% | LENO | 4 | TV host who won a Mark Twain Prize for American Humor |
| 51% | DWAYNEJOHNSON | 13 | "Hobbs & Shaw" actor who won the NAACP Image Award for Entertainer of the Year in 2017: 2 wds. |
| 51% | HAROLDPINTER | 12 | British author of "The Birthday Party" who won the 2005 Nobel Prize in Literature: 2 wds. |
| 51% | WILLSMITH | 9 | "Ali" actor who won the NAACP Image Award for Entertainer of the Year in 1999: 2 wds. |
| 51% | JAMIEFOXX | 9 | "Ray" actor who won the NAACP Image Award for Entertainer of the Year in 2013: 2 wds. |
| 50% | FEY | 3 | Tina who won the 2010 Mark Twain Prize for American Humor |
| 50% | LENO | 4 | Jay who won the 2014 Mark Twain Prize for American Humor |
| 50% | ADAM | 4 | Sandler who won the 2023 Mark Twain Prize for American Humor |
| 50% | RICHARDWILBUR | 13 | American poet behind "Things of This World" who won the Pulitzer Prize in 1957 and 1989: 2 wds. |
| 49% | GEORGECARLIN | 12 | "Brain Droppings" writer/comedian posthumously honored with the 2008 Mark Twain Prize for American Humor (2 wds.) |
| 49% | CARLREINER | 10 | "I Remember Me" writer/comedian honored with the 2000 Mark Twain Prize for American Humor (2 wds.) |
| 49% | BILLYCRYSTAL | 12 | "Still Foolin' 'Em" writer/comedian honored with the 2007 Mark Twain Prize for American Humor (2 wds.) |
| 49% | BILLMURRAY | 10 | Former "Saturday Night Live" comedian honored with the 2016 Mark Twain Prize for American Humor (2 wds.) |