| 100% | CHANDLERBING | 12 | "Friends" roommate played by 41-Across (2 wds.) |
| 87% | OSCARMADISON | 12 | "The Odd Couple" roommate played by 41-Across (2 wds.) |
| 62% | IRONMAN | 7 | Superhero co-created by 41-Across and played by Robert Downey Jr. (2 wds.) |
| 62% | DWAYNEPRIDE | 11 | Special agent played by 19-Across: 2 wds. |
| 62% | HARLEESANTOS | 12 | NYPD detective played by 29-Across: 2 wds. |
| 62% | THIRDBASEMAN | 12 | Position played by 27-Across: 2 wds. |
| 62% | CENTERFIELD | 11 | Position played by 39-Across: 2 wds. |
| 62% | LEFTWING | 8 | Position played by 31-Across: 2 wds. |
| 62% | SHOOTINGGUARD | 13 | Position played by 18-Across: 2 wds. |
| 60% | SILKSTOCKINGS | 13 | 1955 Broadway show with music and lyrics by 41-Across: 2 wds. |
| 59% | MAXGOODWIN | 10 | Hospital medical director played by 16-Across: 2 wds. |
| 58% | MISSCACKLE | 10 | Magic academy headmistress played by Clare Higgins on 41-Across (2 wds.) |
| 58% | PHOEBEBUFFAY | 12 | Character played by Lisa Kudrow in "Friends": 2 wds. |
| 57% | ROSSGELLER | 10 | Geeky character played by David Schwimmer on "Friends": 2 wds. |
| 57% | PHOEBEBUFFAY | 12 | Vegetarian masseuse played by Lisa Kudrow on "Friends": 2 wds. |
| 57% | JAMESGORDON | 11 | Police officer on "Gotham" played by 18-Across: 2 wds. |
| 56% | DWIGHTSCHRUTE | 13 | A character from "The Office" played by Rainn Wilson, who is the nemesis and eventual friend of 42a: 2 wds |
| 56% | UNCLEJESSE | 10 | Role played by 18-Across on "Full House": 2 wds. |
| 56% | MONICAGELLER | 12 | Chef on "Friends" played by Courteney Cox: 2 wds. |
| 56% | PHOEBEBUFFAY | 12 | Masseuse on "Friends" played by Lisa Kudrow: 2 wds. |
| 56% | THEHULK | 7 | 29-Across hero played by Mark Ruffalo: 2 wds. |
| 56% | IZZIESTEVENS | 12 | 14-Across doctor played by Katherine Heigl: 2 wds. |
| 56% | MIRANDABAILEY | 13 | 14-Across doctor played by Chandra Wilson: 2 wds. |
| 55% | LITTLEJOE | 9 | "Bonanza" brother played by 49-Across (2 wds.) |
| 55% | FRANCESFARMER | 13 | 1930s actress played by 44-Across (2 wds.) |
| 55% | MILDREDHUBBLE | 13 | Accident-prone student of magic played by Bella Ramsey on 41-Across (2 wds.) |
| 55% | KELLYBUNDY | 10 | Ditzy character played by 15-/50-Across on "Married... with Children": 2 wds. |
| 55% | EDITHBUNKER | 11 | Housewife played by 29-Across in "All in the Family": 2 wds. |
| 55% | DRWATSON | 8 | Holmes' assistant, played by 29-Across on 47-Across: 2 wds. |
| 55% | DEREKMORGAN | 11 | Special agent played by 39-Across on 29-Across: 2 wds. |