| 100% | MIRANDABAILEY | 13 | "Grey's Anatomy" former chief of surgery played by Chandra Wilson (2 wds.) |
| 86% | MIRANDABAILEY | 13 | "Grey's Anatomy" chief of surgery played by Chandra Wilson (2 wds.) |
| 79% | DEREKSHEPHERD | 13 | "Grey's Anatomy" former chief of surgery played by Patrick Dempsey (2 wds.) |
| 77% | RICHARDWEBBER | 13 | "Grey's Anatomy" former chief of surgery played by James Pickens Jr. (2 wds.) |
| 50% | MIRANDABAILEY | 13 | 14-Across doctor played by Chandra Wilson: 2 wds. |
| 39% | BERNIEMADOFF | 12 | Disgraced former financier played by 17-Across in "The Wizard of Lies": 2 wds. |
| 39% | CHRISODONNELL | 13 | Former "Grey's Anatomy" actor who plays agent Callan on "NCIS: Los Angeles" (2 wds.) |
| 38% | KATHERINEHEIGL | 14 | "Grey's Anatomy" actress who plays Tully Hart on the Netflix adaptation of 41-Across (2 wds.) |
| 37% | MAXWELLSMART | 12 | Agent of CONTROL played by Don Adams: 2 wds. |
| 37% | JORDANBELFORT | 13 | Real-life stock market manipulator played by Leonardo DiCaprio in 2013's "The Wolf of Wall Street": 2 wds. |
| 37% | JACKSPARROW | 11 | Pirate captain played by Johnny Depp in "Pirates of the Caribbean": 2 wds. |
| 36% | ANTHONYNELSON | 13 | Astronaut played by Larry Hagman in "I Dream of Jeannie": 2 wds. |
| 36% | ALFREDBELLOWS | 13 | Psychiatrist played by Hayden Rorke on "I Dream of Jeannie": 2 wds. |
| 36% | BRADBELLICK | 11 | Character played by Wade Williams who is introduced as the captain of Fox River's correctional officers in "Prison Break": 2 wds. |
| 35% | DWIGHTSCHRUTE | 13 | A character from "The Office" played by Rainn Wilson, who is the nemesis and eventual friend of 42a: 2 wds |
| 35% | BAILEY | 6 | Chandra Wilson in Grey's Anatomy |
| 35% | MIKEWHEELER | 11 | Played by Finn Wolfhard, character who is one of Will Byers' three friends in "Stranger Things": 2 wds. |
| 34% | COUNTOLAF | 9 | Villain played by Jim Carrey in "Lemony Snicket's A Series of Unfortunate Events" (2 wds.) |
| 34% | SWEENEYTODD | 11 | Barber played by Johnny Depp in the movie subtitled "The Demon Barber of Fleet Street": 2 wds. |
| 34% | SHADOWMOON | 10 | Husband of the character played by 30a: 2 wds. |
| 33% | DEBBIEALLEN | 11 | "Grey's Anatomy" star who played a dance teacher on "Fame" (2 wds.) |
| 33% | GEORDILAFORGE | 13 | "Star Trek" character played by LeVar Burton, who is the chief engineer of the USS Enterprise-D: 3 wds. |
| 33% | BAILEY | 6 | Former chief resident Miranda on Grey's Anatomy |
| 33% | LUCASMCCAIN | 11 | Fictional rancher played by former athlete 28-Across on 36-Across (2 wds.) |
| 33% | WILHELMKLINK | 12 | POW camp commandant played by Werner Klemperer in "Hogan's Heroes": 2 wds. |
| 33% | PHONETAG | 8 | "Game" played by people who keep missing one another's calls: 2 wds. |
| 33% | LOISLANE | 8 | Reporter played by Amy Adams in "Man of Steel" (2 wds.) |
| 32% | ELLENPOMPEO | 11 | Actress who plays Dr. Meredith Grey on "Grey's Anatomy" (2 wds.) |
| 32% | OLIVERQUEEN | 11 | Real name of Green Arrow, played by Stephen Amell on the CW's "Arrow": 2 wds. |
| 32% | MICHAELGRAY | 11 | "Peaky Blinders" character, played by Finn Cole, who is the son of Polly Gray, the matriarch of the Shelby Family: 2 wds. |