| 100% | EDNA | 4 | "Hairspray" role traditionally played by a man in drag |
| 49% | EDNA | 4 | "Hairspray" mom usually played by a man |
| 45% | TOTO | 4 | Role played by a dog with a bigger salary than some human actors in the same film |
| 45% | EDNA | 4 | Broadway dame played by a man |
| 44% | AMYFISHER | 9 | Role played by Drew Barrymore in a 1993 TV movie based on real life |
| 44% | SUGARPLUMFAIRY | 14 | Role played by 16-Across in a 1954 production of "The Nutcracker": 3 wds. |
| 44% | AMELIA | 6 | Title role played by Hilary Swank in a 2009 biopic |
| 44% | ANNIE | 5 | Musical role played by Quvenzhané Wallis in a 2014 remake |
| 44% | POPEYETHESAILOR | 15 | Nautical role played by Robin Williams in a 1980 film |
| 44% | LILO | 4 | Title role played by Maia Kealoha in a 2025 remake |
| 43% | TONY | 4 | ___ Stark, character played by Robert Downey Jr. in the "Iron Man" film series who sports a distinctive iconic goatee |
| 43% | PORTHOS | 7 | Classic role played by Gérard Depardieu in "The Man in the Iron Mask" |
| 43% | CHARLIEWILSON | 13 | Title role played by Tom Hanks in a 2007 comedy-drama: 2 wds. |
| 43% | LARRYCROWNE | 11 | Title role played by Tom Hanks in a 2011 romantic comedy: 2 wds. |
| 42% | KILLERJOE | 9 | Title hit man played by Matthew McConaughey in a 2011 film |
| 42% | FORRESTGUMP | 11 | Title role played by Tom Hanks in a 1994 Oscar-winning movie: 2 wds. |
| 41% | MARTYR | 6 | Role played by a sufferer, maybe |
| 41% | ELIZABETH | 9 | Queen played by 15-Across in "Shakespeare in Love," a role for which she won a Best Supporting Actress Oscar |
| 40% | NEO | 3 | Role first played by Keanu Reeves in 1999 |
| 40% | PART | 4 | Role in a play |
| 40% | PARTS | 5 | Roles in a play |
| 40% | ROLE | 4 | Part played by individual in a drama |
| 40% | PART | 4 | Role in a play, say |
| 40% | ACT | 3 | Play a role in movies |
| 39% | ETTA | 4 | James played by Beyoncé in a 2008 biopic |
| 39% | ACRE | 4 | Traditionally, amount of land plowable by one man in one day with a team of oxen |
| 39% | ACTED | 5 | Played a role in a play |
| 39% | ONEUPON | 7 | Beating by a hole, in match play |
| 39% | ACT | 3 | Play a role in a play |
| 39% | ACT | 3 | Play the role, in a play |