| 100% | MADSMIKKELSEN | 13 | "Hannibal" actor who plays the villain Kaecilius in 32-Across: 2 wds. |
| 68% | MADSMIKKELSEN | 13 | "Doctor Strange" actor who plays the villain in the new 17-Across movie: 2 wds. |
| 67% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 64% | MICHAELKEATON | 13 | Actor who plays Vulture, the villain in 16-Across: 2 wds. |
| 64% | SPENCERTRACY | 12 | Actor who played the lawyer based on Clarence Darrow in 32-Across: 2 wds. |
| 63% | FREDRICMARCH | 12 | Actor who played the lawyer based on William Jennings Bryan in 32-Across: 2 wds. |
| 62% | SHAWNHATOSY | 11 | "In & Out" actor who plays the son Andrew "Pope" Cody in 32-Across: 2 wds. |
| 62% | EWANMCGREGOR | 12 | Actor who played 29-/32-Across in the 1990s and 2000s: 2 wds. |
| 62% | ALECGUINNESS | 12 | Actor who played 29-/32-Across in the 1970s and 1980s: 2 wds. |
| 62% | JOSHBROLIN | 10 | Actor who plays the fixer in 18-Across: 2 wds. |
| 61% | JIMCARREY | 9 | "The Mask" actor who plays the villain Dr. Robotnik in the 2020 video-game movie "Sonic the Hedgehog": 2 wds. |
| 61% | JASONBIGGS | 10 | "American Pie" actor who plays the father in 18-Across: 2 wds. |
| 61% | ANTHONYHOPKINS | 14 | Welsh-born actor who played Hannibal Lecter in "The Silence of the Lambs": 2 wds. |
| 60% | JOSHOCONNOR | 11 | "Emma" actor who played 32-Across in seasons 3 and 4 of "The Crown": 2 wds. |
| 60% | SAMROCKWELL | 11 | Actor who plays the father in the 2015 remake of 18-Across: 2 wds. |
| 60% | RAULJULIA | 9 | "The Addams Family" actor who played the villain Bison in the 1994 video-game movie "Street Fighter": 2 wds. |
| 60% | PETERSELLERS | 12 | Actor who played Pres. Merkin Muffley, Group Capt. Lionel Mandrake, and the title character in 32-Across: 2 wds. |
| 60% | DOMINICWEST | 11 | "The Wire" actor who plays 32-Across in season 5 of "The Crown": 2 wds. |
| 59% | ERICBANA | 8 | Actor who played 32-Across in a 2003 film: 2 wds. |
| 59% | EDWARDNORTON | 12 | Actor who played 32-Across in a 2008 film: 2 wds. |
| 59% | MADSMIKKELSEN | 13 | "Hannibal" actor who played a Bond villain in 2006's "Casino Royale": 2 wds. |
| 59% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 58% | ZACHARYLEVI | 11 | "Chuck" actor who plays the grown-up superhero version of 38-Across in "Shazam!": 2 wds. |
| 58% | COREYFELDMAN | 12 | "Stand by Me" actor who played the Petersons' neighbor, Ricky Butler, in 50-Across: 2 wds. |
| 58% | CHACECRAWFORD | 13 | Actor who plays the key male character in "Gossip Girl": 2 wds. |
| 58% | RAYBOLGER | 9 | Actor who played the Scarecrow in "The Wizard of Oz": 2 wds. |
| 58% | DUSTINHOFFMAN | 13 | Actor who played 43-Across in the movie "All the President's Men": 2 wds. |
| 57% | MARKRUFFALO | 11 | Actor who played the Hulk in the Avengers movies: 2 wds. |
| 57% | JASONBATEMAN | 12 | "Game Night" actor who plays The Crab in 37-Across (2 wds.) |
| 57% | DANAYKROYD | 10 | "Ghostbusters" actor who plays the Scarecrow in "Legends of Oz": 2 wds. |