| 100% | RONHOWARD | 9 | "Happy Days" actor who directed "Apollo 13" and "A Beautiful Mind": 2 wds. |
| 55% | HOWARD | 6 | Ron, director of Apollo 13 and A Beautiful Mind |
| 52% | TOMHANKS | 8 | "A Beautiful Day in the Neighborhood" actor who plays astronaut Jim Lovell in the docudrama about failed 1970 lunar mission Apollo 13 (2 wds.) |
| 52% | JONFAVREAU | 10 | Actor who plays Happy Hogan in Marvel films, and has directed the pilot for "The Orville": 2 wds. |
| 50% | BRADLEYCOOPER | 13 | "American Sniper" actor who directed and stars in the "A Star Is Born" remake: 2 wds. |
| 49% | WARRENBEATTY | 12 | Actor who directed, wrote, and appears in "Rules Don't Apply": 2 wds. |
| 48% | ORSONWELLES | 11 | Actor who directed 17-Across and played the title character: 2 wds. |
| 48% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 47% | ROBERTREDFORD | 13 | "All Is Lost" actor who directed and starred in "The Horse Whisperer": 2 wds. |
| 46% | RONHOWARD | 9 | "A Beautiful Mind" director who is a Tony away from completing the EGOT: 2 wds. |
| 46% | PAULBETTANY | 11 | "A Beautiful Mind" actor who plays Vision in the Disney+ show "WandaVision": 2 wds. |
| 46% | RUSSELLCROWE | 12 | "A Beautiful Mind" actor who was born in New Zealand in 1964: 2 wds. |
| 45% | GEORGECLOONEY | 13 | Actor who starred in and made his directorial debut with 2002's "Confessions of a Dangerous Mind": 2 wds. |
| 45% | ROBREINER | 9 | "All in the Family" actor who directed "The Princess Bride" and "When Harry Met Sally ...": 2 wds. |
| 45% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 45% | CHRISPERFETTI | 13 | "Looking" actor who plays a history teacher and ally of 15-Across: 2 wds. |
| 44% | ASHTONKUTCHER | 13 | Actor who replaced Charlie Sheen on "Two and a Half Men": 2 wds. |
| 44% | LESLIENIELSEN | 13 | "Airplane!" actor who played a vampire in the comedy "Dracula: Dead and Loving It": 2 wds. |
| 44% | RUSSELLCROWE | 12 | "A Beautiful Mind" star who plays the father in "Boy Erased": 2 wds. |
| 43% | EDWARDNORTON | 12 | "Fight Club" actor who plays Lionel Essrog in "Motherless Brooklyn" and also directed the film: 2 wds. |
| 43% | JEFFDANIELS | 11 | Actor who won a 2013 Emmy for playing Will McAvoy, the anchor and managing editor on 37-Across: 2 wds. |
| 43% | ANTHONYHOPKINS | 14 | "The Silence of the Lambs" actor who played a butler in "The Remains of the Day": 2 wds. |
| 43% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 42% | JONFAVREAU | 10 | Actor who plays Happy Hogan in the Marvel movies, and plays the same role in the upcoming "Spider-Man: Homecoming": 2 wds. |
| 42% | JUDDNELSON | 10 | Actor who played a high school delinquent in "The Breakfast Club" and a yuppie politician in "St. Elmo's Fire": 2 wds. |
| 42% | EMILIOESTEVEZ | 13 | Actor who played a high school jock in "The Breakfast Club" and a law student in "St. Elmo's Fire": 2 wds. |
| 42% | ROWANATKINSON | 13 | Actor who voiced Zazu, a hornbill in "The Lion King" and is best known for his role as Mr. Bean: 2 wds. |
| 42% | MICHAELKEATON | 13 | "Spotlight" actor who has played a Marvel supervillian in "Spider-Man: Homecoming" and a DC superhero in "Batman": 2 wds. |
| 42% | RYANREYNOLDS | 12 | "Definitely, Maybe" actor who has played a Marvel superhero in "Deadpool" and a DC superhero in "Green Lantern": 2 wds. |
| 42% | BOBODENKIRK | 11 | "Better Call Saul" actor who auctioned a dinner with himself and David Cross to benefit the WGA strike: 2 wds. |