| 100% | SICK | 4 | "I'm ___ and tired of you!" |
| 76% | SICK | 4 | "I'm ___ and tired of it all!" |
| 65% | PETERFRAMPTON | 13 | Singer of “I'm in You” and “Baby, I Love Your Way” |
| 65% | PAULSIMON | 9 | Singer of You Can Call Me Al and Kodachrome |
| 65% | WEASEL | 6 | You and I organise sale of animal |
| 65% | USAGE | 5 | You and me have period of employment |
| 65% | WEASEL | 6 | You and I organise sale of creature |
| 64% | BEBEREXHA | 9 | Singer of I'm Gonna Show You Crazy and I'm a Mess |
| 63% | AMSO | 4 | "I ___ sick and tired of this!": 2 wds |
| 62% | BARTSTARR | 9 | M.V.P. of Super Bowls I and II |
| 61% | JOJOMOYES | 9 | Romance novelist of Me Before You and Still Me |
| 61% | CAMPUS | 6 | Place of learning is effeminate to you and me |
| 60% | SAMCOOKE | 8 | King of Soul, sang You Send Me and Wonderful World |
| 60% | PAULSIMON | 9 | Singer of Graceland album and You Can Call Me Al |
| 59% | LOBO | 4 | 1970s singer of Me and You and a Dog Named Boo |
| 59% | RITAORA | 7 | Singer of How We Do (Party) and Let You Love Me |
| 57% | THEN | 4 | Fats Waller's "___ I'll Be Tired of You" |
| 57% | OWEN | 4 | Actor Wilson of "You, Me and Dupree" |
| 56% | NYE | 3 | Simon —, creator of sitcoms How Do You Want Me?, Is It Legal? and Hardware |
| 56% | MICHAELA | 8 | Coel, writer and star of I May Destroy You |
| 56% | FED | 3 | ___ up with (sick and tired of) |
| 55% | ASET | 4 | "Should I get ___ of whitewall tires?" ("It's Still Rock and Roll to Me" lyric) |
| 55% | PEIS | 4 | I. M. and Mario |
| 55% | LOLLIPOP | 8 | I'm tired of getting the fuzzy end of the __ |
| 55% | PEI | 3 | Rock and Roll Hall of Fame architect I. M. ___ |
| 55% | ALI | 3 | Who said "If you even dream of beating me, you'd better wake up and apologize" |
| 55% | ALI | 3 | He said "If you even dream of beating me, you'd better wake up and apologize" |
| 54% | NOBODY | 6 | I'm __. Who are you? Then there's a pair of us |
| 53% | AHEAD | 5 | "I'm way ___ of you" |