| 100% | BOBNEWHART | 10 | "I Shouldn't Even Be Doing This!" writer/comedian honored with the 2002 Mark Twain Prize for American Humor (2 wds.) |
| 67% | CARLREINER | 10 | "I Remember Me" writer/comedian honored with the 2000 Mark Twain Prize for American Humor (2 wds.) |
| 61% | BILLYCRYSTAL | 12 | "Still Foolin' 'Em" writer/comedian honored with the 2007 Mark Twain Prize for American Humor (2 wds.) |
| 59% | GEORGECARLIN | 12 | "Brain Droppings" writer/comedian posthumously honored with the 2008 Mark Twain Prize for American Humor (2 wds.) |
| 59% | BILLMURRAY | 10 | Former "Saturday Night Live" comedian honored with the 2016 Mark Twain Prize for American Humor (2 wds.) |
| 59% | DAVECHAPPELLE | 13 | Former "Saturday Night Live" comedian honored with the 2019 Mark Twain Prize for American Humor (2 wds.) |
| 59% | LILYTOMLIN | 10 | Former "Saturday Night Live" comedian honored with the 2003 Mark Twain Prize for American Humor (2 wds.) |
| 43% | LORNEMICHAELS | 13 | "Saturday Night Live" creator who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 43% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 42% | EDDIEMURPHY | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 42% | WILLFERRELL | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 41% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 40% | WILLFERRELL | 11 | "Elf" actor who roasted 2025 Mark Twain Prize for American Humor honoree Conan O'Brien: 2 wds. |
| 39% | STEVEMARTIN | 11 | "Father of the Bride" actor who won the Mark Twain Prize for American Humor in 2005: 2 wds. |
| 37% | EDDIEMURPHY | 11 | "The Nutty Professor" actor and "SNL" star who won the Mark Twain Prize for American Humor in 2015: 2 wds. |
| 37% | WILLFERRELL | 11 | "Elf" actor and "Saturday Night Live" star who won the Mark Twain Prize for American Humor in 2011: 2 wds. |
| 36% | CONAN | 5 | O’Brien who was awarded the Mark Twain Prize for American Humor, in 2025 |
| 36% | PRYOR | 5 | Recipient of the inaugural Mark Twain Prize for American Humor |
| 35% | NIGHTFEVER | 10 | 1978 #1 hit with the lyrics "Here I am, praying for this moment to last": 2 wds. |
| 35% | FEY | 3 | Tina who won the 2010 Mark Twain Prize for American Humor |
| 35% | LENO | 4 | Jay who won the 2014 Mark Twain Prize for American Humor |
| 35% | ADAM | 4 | Sandler who won the 2023 Mark Twain Prize for American Humor |
| 35% | EDDIE | 5 | Murphy with a Mark Twain Prize for American Humor |
| 34% | FEY | 3 | Tina who won the Mark Twain Prize for American Humor |
| 34% | LENO | 4 | 2014 winner of the Mark Twain Prize for American Humor |
| 34% | FEY | 3 | 2010 recipient of the Mark Twain Prize for American Humor |
| 34% | XXXXXXXXXX | 10 | 2022 winner of the Mark Twain Prize for American Humor |
| 34% | FEY | 3 | Youngest recipient of the Mark Twain Prize for American Humor (2010) |
| 34% | LENO | 4 | Jay who won the Mark Twain Prize for American Humor in 2014 |
| 33% | LENO | 4 | 2014 Mark Twain Prize for American Humor recipient |