| 100% | OUR | 3 | "It is the night of ___ dear Savior's birth" |
| 48% | BREVITY | 7 | It is the soul of wit |
| 48% | WANNSEE | 7 | It is the westernmost locality of Berlin |
| 47% | VARIETY | 7 | It is the spice of life, proverbially speaking |
| 47% | CROSSOFGOLDSPEECH | 17 | It was the talk of Chicago, July 1896 |
| 47% | ISTANBUL | 8 | It was the capital of Turkey until 1923 |
| 47% | ANAL | 4 | Felix's description, it being the exact opposite of Oscar Madison |
| 47% | NOOSE | 5 | The loop it's best to be out of |
| 47% | DELHI | 5 | It was the capital of British India after Calcutta |
| 46% | LPGATOUR | 8 | The U.S. Women's Open is part of it |
| 45% | OED | 3 | It's 2021 word of the year was "vax" |
| 45% | NPR | 3 | Broadcaster of the podcast It's Been a Minute |
| 45% | CFT | 3 | The Marine's “Maneuver Under Fire” drill is part of it (abbr.) |
| 45% | HORSEMEN | 8 | It's said four of these will bring the apocalypse |
| 45% | BEAUTY | 6 | It is in the eye of the beholder |
| 45% | CANADA | 6 | It was invaded in the War of 1812 |
| 44% | GERIHALLIWELL | 13 | Birth name of the Spice Girl who released the solo single "It's Raining Men," and was nicknamed "Ginger Spice": 2 wds. |
| 44% | THEY | 4 | Its singular form was named Merriam-Webster's 2019 Word of the Year |
| 44% | METOOMOVEMENT | 13 | Its members were collectively awarded Time magazine's 2017 Person of the Year |
| 44% | MOON | 4 | It's always full the night of the Mid-Autumn Festival |
| 44% | ERR | 3 | It is better to ___ on the side of caution |
| 44% | VARIETY | 7 | It's said to be the spice of life |
| 44% | TULANE | 6 | It was founded as the Medical College of Louisiana |
| 44% | MEMORY | 6 | Amnesia is the medical loss of it |
| 44% | HUNT | 4 | Diana is the Roman goddess of it |
| 44% | WAR | 3 | Mars is the Roman god of it |
| 44% | EEL | 3 | Anago is the saltwater kind of it |
| 44% | EEL | 3 | Unagi is the freshwater variety of it |
| 44% | SEA | 3 | Neptune was the Roman god of it |
| 44% | BIBLE | 5 | With 4-Down, much of the Southeast U.S. is in it |