| 100% | ADOG | 4 | "It shouldn't happen to —" |
| 95% | ADOG | 4 | "It shouldn't happen to ___": 2 wds. |
| 94% | AVET | 4 | "It Shouldn't Happen to ___" (James Herriot book) |
| 81% | HERRIOT | 7 | James —, author of semi-autobiographical novels It Shouldn't Happen to a Vet and Vets Might Fly |
| 67% | LETMEHELP | 9 | "You shouldn't have to do it all alone" |
| 65% | FATE | 4 | It's bound to happen |
| 62% | BALLOTBOX | 9 | It shouldn't be stuffed |
| 62% | BADADVICE | 9 | It shouldn’t be taken |
| 61% | ITS | 3 | "If ___ meant to happen, it will..." |
| 60% | SUEDE | 5 | Type of boots you likely shouldn't wear if it looks like it's going to pour down |
| 60% | BODYSHOP | 8 | It may be waiting for an accident to happen |
| 60% | LOOM | 4 | Seem like it's about to happen |
| 59% | MOLAR | 5 | It shouldn't be used as an icebreaker |
| 59% | BIGIF | 5 | It's very unlikely to happen |
| 58% | GAS | 3 | It shouldn't be passed at the dinner table |
| 57% | ETHANOL | 7 | The Model T was designed to run on it |
| 57% | GAGA | 4 | "Til It Happens to You" singer Lady ___ |
| 57% | TIL | 3 | "___ It Happens to You" (Gaga song) |
| 57% | AGIRLCANDREAM | 13 | “It might never happen . . . but it’s fun to fantasize” |
| 57% | APR | 3 | It is the cruelest month according to T.S. Eliot, for short |
| 57% | CART | 4 | It shouldn't be put before the horse, they say |
| 56% | TIL | 3 | "___ It Happens to You" (Lady Gaga song) |
| 56% | AFIRST | 6 | It hasn't happened before |
| 56% | ASNO | 4 | "It came ___ surprise to me" ("I knew it would happen!"): 2 wds. |
| 56% | HAD | 3 | "It ___ to happen" |
| 55% | ADOPTION | 8 | For a puppy, it usually happens at seven to nine weeks |
| 55% | CGI | 3 | It brought a T. rex to life in "Jurassic Park" |
| 55% | ITSASIN | 7 | "That just shouldn't happen" |
| 55% | SCAB | 4 | You shouldn’t pick it |
| 55% | LIE | 3 | You shouldn't believe it |