| 100% | CHRISEVANS | 10 | "Knives Out" actor who voices the title character in "Lightyear" (2 wds.) |
| 80% | MICHAELCERA | 11 | "Arrested Development" actor who voices the title character in Netflix's "Scott Pilgrim Takes Off": 2 wds. |
| 71% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 71% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 71% | MIKEMYERS | 9 | "SNL" cast member (1989-1995) who voiced the title character in the "Shrek" movies: 2 wds. |
| 70% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 69% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 68% | JAMESCORDEN | 11 | "The Late Late Show" host who voices the title character in 18-Across: 2 wds. |
| 68% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 68% | WILLARNETT | 10 | "Arrested Development" actor who voices the title character on 32-Across (2 wds.) |
| 68% | DEPP | 4 | Actor who voiced the title character in 2018's "Sherlock Gnomes" |
| 67% | MICHAELCIMINO | 13 | "Annabelle Comes Home" actor who plays the newly out title character in "Love, Victor": 2 wds. |
| 66% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 65% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 65% | SETH | 4 | MacFarlane who voices the title character in the upcoming "Ted 2" |
| 64% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 63% | ANSELELGORT | 11 | "The Fault in Our Stars" actor who plays the title character in "Baby Driver": 2 wds. |
| 63% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 63% | CHANNINGTATUM | 13 | "The Vow'' actor who voices one of the lead characters in "Smallfoot'': 2 wds. |
| 62% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 62% | ROBERTDENIRO | 12 | "Joy" actor who plays the title character in 18-Across: 3 wds. |
| 62% | IRENEBEDARD | 11 | Actress who voiced the title role in "Pocahontas": 2 wds. |
| 60% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 59% | TIMALLEN | 8 | "The Santa Clause" actor who voices Buzz Lightyear in the "Toy Story" films (2 wds.) |
| 59% | HUGHJACKMAN | 11 | "Logan" actor who voiced the rodent Roddy St. James in "Flushed Away": 2 wds. |
| 59% | TIMALLEN | 8 | "Home Improvement" actor who voiced Buzz Lightyear in "Toy Story": 2 wds. |
| 59% | BILLYEICHNER | 12 | "Bros" actor who voices Timon in "Mufasa: The Lion King": 2 wds. |
| 59% | STEVENYEUN | 10 | Actor who voices Bo the donkey in the movie "The Star": 2 wds. |
| 59% | TYLERPERRY | 10 | Actor who voices Cyrus the camel in the movie "The Star": 2 wds. |
| 58% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |