| 100% | ENROSE | 6 | "La Vie ___," 2007 biopic on French singer Edith Piaf that stars Marion Cotillard in the lead role: 2 wds. |
| 37% | BLACKLIGHTNING | 14 | CW show that stars Cress Williams in the lead superhero role: 2 wds. |
| 34% | MILEYCYRUS | 10 | "Party in the U.S.A." singer whose first TV series lead role was on Disney's "Hannah Montana": 2 wds. |
| 32% | LADY | 4 | "___ Sings the Blues," 1972 biopic on Billie Holiday that stars Diana Ross in the lead role |
| 31% | ROCKETMAN | 9 | 2019 biopic on Elton John starring Taron Egerton in the lead role |
| 29% | TOMCRUISE | 9 | "Mission Impossible" star who turned down the lead role in the classic film "Footloose": 2 wds. |
| 29% | FRIENDSWITH | 11 | "___ Benefits," 2011 romantic comedy film that starred Justin Timberlake and Mila Kunis in the lead roles: 2 wds. |
| 28% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 28% | BOBODENKIRK | 11 | "Breaking Bad" actor who plays the lead role on 33-Across: 2 wds. |
| 28% | MATTSMITH | 9 | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| 28% | DAVIDTENNANT | 12 | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| 28% | ALI | 3 | Sports biopic that starred Will Smith in the title role |
| 28% | PETERCAPALDI | 12 | Twelfth actor to play the lead role in 15-Across, starting in 2013: 2 wds. |
| 28% | MELGIBSON | 9 | "Lethal Weapon" and "Braveheart" actor who turned down the lead role in "Gladiator": 2 wds. |
| 27% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 27% | ULEE | 4 | Lead role in the film known in France as "L'Or de la Vie" |
| 27% | FUNNYGAMES | 10 | A 2007 psychological thriller starring Naomi Watts - whose birthday it is today - in the lead role alongside Tim Roth: 2 wds. |
| 27% | THEJEFFERSONS | 13 | "All in the Family" spin-off that starred Sherman Hemsley: 2 wds. |
| 27% | JENNIFERLOPEZ | 13 | Singer famous for her hit song "On the Floor" with Pitbull, who also starred as the lead role in the film "Maid in Manhattan": 2 wds. |
| 27% | THECONTRACTOR | 13 | 2007 American action film starring Lena Headey, that was released on direct-to DVD in the US: 2 wds. |
| 27% | DOCTORWHO | 9 | British sci-fi show that cast Peter Capaldi in the starring role in 2013: 2 wds. |
| 27% | DOCTORSTRANGE | 13 | Marvel superhero movie starring Benedict Cumberbatch in the title role: 2 wds. |
| 27% | ANNIESPOINT | 11 | 2005 TV movie starring Betty White in the titular role: 2 wds. |
| 26% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |
| 26% | THEMANDALORIAN | 14 | Disney+ space western starring Pedro Pascal in the title role: 2 wds. |
| 26% | BRYANCRANSTON | 13 | American actor who played the lead in "Breaking Bad" and also starred in "Malcolm in the Middle": 2 wds. |
| 26% | CHARLIE | 7 | & 25A 2007 biopic starring Tom Hanks in the title role |
| 26% | LEEMAYE | 7 | Former MLB player who was also the lead singer for an LA-based doo-wop group: 2 wds. |