| 100% | JAMESBROLIN | 11 | "Life in Pieces" actor who played Dr. Steve Kiley on 30-Across (2 wds.) |
| 55% | JONAHHILL | 9 | "Moneyball" actor who plays himself in 30-/32-Across: 2 wds. |
| 55% | JASONMOMOA | 10 | Actor who plays Aquaman in 30-Across: 2 wds. |
| 55% | BENAFFLECK | 10 | Actor who plays Batman in 30-Across: 2 wds. |
| 55% | JACKCOLEMAN | 11 | "Dynasty" actor who plays Noah Bennet on 30-/32-Across: 2 wds. |
| 55% | ZACHARYLEVI | 11 | "Chuck" actor who plays Luke Collins on 30-/32-Across: 2 wds. |
| 55% | SETHROGEN | 9 | "Knocked Up" actor who plays himself in 30-/32-Across: 2 wds. |
| 54% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 54% | SPENCERTRACY | 12 | Actor who played the lawyer based on Clarence Darrow in 32-Across: 2 wds. |
| 53% | MANNYJACINTO | 12 | Actor who played Yao on "Nine Perfect Strangers" and costarred in 29- and 42-Across: 2 wds. |
| 53% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 53% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 52% | FREDRICMARCH | 12 | Actor who played the lawyer based on William Jennings Bryan in 32-Across: 2 wds. |
| 52% | JUDELAW | 7 | "Alfie" actor who played Dr. Watson in the movie "Sherlock Holmes": 2 wds. |
| 52% | ANSELELGORT | 11 | "Baby Driver" actor who plays Theo in 30-Across: 2 wds. |
| 52% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 52% | EDMUNDGWENN | 11 | Actor who played Kris Kringle in 1947's "Miracle on 34th Street": 2 wds. |
| 52% | JAREDLETO | 9 | "Suicide Squad" actor who plays Dr. Michael Morbius in the upcoming movie "Morbius": 2 wds. |
| 51% | FREDMACMURRAY | 13 | Actor who played widowed father Steve Douglas on "My Three Sons": 2 wds. |
| 51% | JAMESSTEWART | 12 | Actor who plays 14-Across in "It's a Wonderful Life" (2 wds.) |
| 51% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 51% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane in "Frasier" and "Cheers", and hosted the 1998 Grammy Awards: 2 wds. |
| 51% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 51% | JACKBLACK | 9 | "Kung Fu Panda 4" actor who plays Steve in "A Minecraft Movie": 2 wds. |
| 51% | PETERUSTINOV | 12 | Actor who played Hercule Poirot in the 1978 film "Death on the Nile": 2 wds. |
| 51% | OAKESFEGLEY | 11 | "Pete's Dragon" actor who plays young Theo in 30-Across: 2 wds. |
| 51% | KENNETHBRANAGH | 14 | "Tenet" actor who plays Hercule Poirot in "Death on the Nile": 2 wds. |
| 50% | CHARLIEHUNNAM | 13 | Actor who plays 30-Across on 46-Across (2 wds.) |
| 50% | ALBERTFINNEY | 12 | Actor who played Hercule Poirot in the 1974 film "Murder on the Orient Express": 2 wds. |
| 50% | DWAYNEJOHNSON | 13 | Actor who plays Dr. Smolder Bravestone in "Jumanji: Welcome to the Jungle" (2 wds.) |