| 100% | DORRIT | 6 | "Little ___" (18-/41-Across novel set in a debtors' prison) |
| 48% | SNOW | 4 | Orhan Pamuk novel set in a blizzard |
| 48% | TARA | 4 | Setting in a Mitchell novel |
| 48% | COMA | 4 | 1977 best-selling novel set in a hospital |
| 47% | LONESOMEDOVE | 12 | 1986 Pulitzer-winning novel set in a cattle drive |
| 47% | NEEDFULTHINGS | 13 | Stephen King novel set in a gift shop (2 wds.) |
| 46% | MAIN | 4 | "___ Street" (Sinclair Lewis novel set in a small town in Minnesota) |
| 46% | THENICKELBOYS | 13 | Colson Whitehead novel set in a Florida reform school (3 wds.) |
| 46% | COOLHANDLUKE | 12 | 1967 film set in a prison camp |
| 45% | THENICKELBOYS | 13 | 2019 Colson Whitehead novel set in a Florida reform school (3 wds.) |
| 45% | THEMAGICIANS | 12 | Lev Grossman novel set in a school for aspiring sorcerers (2 wds.) |
| 45% | HANMA | 5 | Baki __, Japanese anime series set in a prison |
| 45% | OMOO | 4 | 1847 novel set in part aboard a whaler |
| 45% | MILE | 4 | "The Green ___" (Tom Hanks film set in a prison) |
| 43% | CHAPLAIN | 8 | Priest in a prison or military setting |
| 42% | DELIVERANCE | 11 | 1972 thriller set in the backwoods of Georgia … or a plot point in 18-, 29- and 49-Across? |
| 42% | DORRIT | 6 | “Little ___” (Dickens novel about a girl born and raised in a debtors’ prison) |
| 41% | ORANGEIS | 8 | With 33- and 52-Across, television series set in a women's prison: 2 wds. |
| 41% | AMERICANRUST | 12 | Novel by 31-Across set in a declining Pennsylvania steel town (2 wds.) |
| 40% | THEBLACKTULIP | 13 | Alexandre Dumas historical novel set in Holland that has a flower in its title (3 wds.) |
| 40% | EMPRESSORCHID | 13 | Anchee Min historical novel set in China that has a flower in its title (2 wds) |
| 40% | SULA | 4 | 1973 novel set in "the Bottom," a neighborhood slated to be demolished for a golf course |
| 40% | EYRE | 4 | "The ___ Affair" (murder mystery set in the universe of a Brontë novel) |
| 39% | DUNCES | 6 | A Confederacy of __, novel set in New Orleans |
| 39% | AMYANDISABELLE | 14 | Elizabeth Strout novel set in the fictional town of Shirley Falls about a mother and daughter (3 wds.) |
| 39% | WHITEOLEANDER | 13 | Janet Fitch coming-of-age novel set in Los Angeles that has a flower in its title (2 wds.) |
| 38% | CORKOCONNOR | 11 | Former small-town sheriff featured in a series of novels by William Kent Krueger, including "Iron Lake," 18-Across, and 29-Across (2 wds.) |
| 38% | OMOO | 4 | Novel set in Tahiti |
| 38% | DINETTE | 7 | Set in a kitchen |
| 38% | DIALS | 5 | Set in a cockpit |